MTNR1B - melatonin receptor 1B Gene

Also Known as MT2; FGQTL2; MEL-1B-R

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4544

About MTNR1B

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:92,969,651-92,984,960 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 33 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1B Products (3)

mRNA Protein Name
XM_017017777.2 XP_016873266.1 melatonin receptor type 1B isoform X1
NM_005959.5 NP_005950.1 melatonin receptor type 1B
XM_011542839.3 XP_011541141.1 melatonin receptor type 1B isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20859254 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
20668700 GOA
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
20668700 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTNR1B Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 308)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

melatonin receptor type 1B

  • mel1b receptor

  • melatonin receptor MEL1B

MTNR1B Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MTNR1B P49286 RGS20 Homo sapiens O76081
Anti Tag CoIP
20859254
Intra
MTNR1B P49286 MTNR1A Homo sapiens P48039
Anti Tag CoIP
20859254
Intra
MTNR1B P49286 TRIP12 Homo sapiens Q14669
Y2H
26514267
Intra
MTNR1B P49286 HTR2C Homo sapiens P28335
Anti Tag CoIP
25770211
Intra
MTNR1B P49286 HTR2C Homo sapiens P28335
IF
25770211
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Scoliosis
Glucose Intolerance

  • Glucose: Intolerance

  • Glucose: Malabsorption

  • Malabsorption Of Glucose

  • Impaired Glucose Tolerance
Wolfram Syndrome 1

  • WFS1

  • Didmoad

  • Wfs

  • Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

  • Wolfram Syndrome
Idiopathic Scoliosis

  • Scoliosis Idiopathic
Spermatogenic Failure 24

  • SPGF24

  • Spermatogenic Failure, Type 24
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diabetes Mellitus

  • Diabetes
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Diabetes Mellitus, Non-Insulin-Dependent

  • Type 2 Diabetes

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08806 MTNR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08807 Mtnr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08808 Mtnr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus MTNR1B VGNC VGNC:68351
Mus musculus MTNR1B MGD MGI:2181726
Canis familiaris MTNR1B VGNC VGNC:52269
Rattus norvegicus MTNR1B RGD RGD:620798
Others MTNR1B NCBI