NME2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

Also Known as PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4831

About NME2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:51,165,536-51,171,744 (from NCBI)

This gene has 9 transcripts (splice variants), 118 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues.

Summary

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

NME2 Products (5)

mRNA	Protein	Name
NM_001018137.3	NP_001018147.1	nucleoside diphosphate kinase B isoform a
NM_001018138.1	NP_001018148.1	nucleoside diphosphate kinase B isoform a
NM_001018139.2	NP_001018149.1	nucleoside diphosphate kinase B isoform a
NM_001198682.2	NP_001185611.1	nucleoside diphosphate kinase B isoform b
NM_002512.4	NP_002503.1	nucleoside diphosphate kinase B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA binding	IDA IDA: Inferred from direct assay	19435876	GOA
enables G-quadruplex DNA binding	IDA IDA: Inferred from direct assay	25679041	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	19435876	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	1851158	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11919189	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	8392752	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11919189	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in nucleoside triphosphate biosynthetic process	IDA IDA: Inferred from direct assay	1851158	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8392752	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19435876	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	16862176	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15703214	GOA
involved in regulation of epidermis development	IMP IMP: Inferred from mutant phenotype	16862176	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cell periphery	IDA IDA: Inferred from direct assay	11919189	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15703214	GOA
NOT located in focal adhesion	IDA IDA: Inferred from direct assay	11919189	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11919189	GOA
located in ruffle	IDA IDA: Inferred from direct assay	11919189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nucleoside diphosphate kinase B	HEL-S-155an

NME2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NME2	P22392	ITGB1BP1	Homo sapiens	O14713-1	Anti Bait CoIP	11919189
Intra	NME2	P22392	ITGB1BP1	Homo sapiens	O14713-1	Pull Down	11919189
Intra	NME2	P22392	ITGB1BP1	Homo sapiens	O14713-1	ELISA	11919189
Intra	NME2	P22392	NME3	Homo sapiens	Q13232	Anti Tag CoIP	33961781
Intra	NME2	P22392	NME2	Homo sapiens	P22392	Anti Tag CoIP	33961781
Intra	NME2	P22392	NME2	Homo sapiens	P22392	Y2H	21988832
Intra	NME2	P22392	NME4	Homo sapiens	O00746	Y2H	21988832
Intra	NME2	P22392	NME1	Homo sapiens	P15531	Pull Down	17314099
Intra	NME2	P22392	NME4	Homo sapiens	O00746	Anti Tag CoIP	33961781
Intra	NME2	P22392	NME1	Homo sapiens	P15531	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

NME2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83223	NME2 Antibody (YA2968)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84187	NME2 Antibody (YA3884)	WB, IHC-P, ELISA	Human
HY-P84187A	NME2 Antibody (YA3884)(PBS only)	WB, IHC-P, ELISA	Human

Diseases	Alias
Endometrium Carcinoma In Situ	Carcinoma In Situ Of Endometrium Endometrial Carcinoma In Situ
Nemaline Myopathy 2	NEM2 Nemaline Myopathy 2, Autosomal Recessive Nemaline Myopathy, Type 2 Neb-Related Nemaline Myopathy Myopathy, Nemaline, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-N6747	Stauprimide	Inhibitor	99.45%	Unkown
HY-W591768	(E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide		99.66%	Unkown
HY-RS09373	NME2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-170436	NFh-NMe-2	Inducer	/	Unkown
HY-RS09372	NME1-NME2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19360	Nme2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25852	Nme2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	NME2	VGNC	VGNC:108102
Rattus norvegicus	NME2	RGD	RGD:619877
Mus musculus	NME2	MGD	MGI:97356