DNAJC7 - DnaJ heat shock protein family (Hsp40) member C7 Gene

Also Known as DJ11; DJC7; TPR2; TTC2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7266

About DNAJC7

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,976,435-42,017,439 (from NCBI)

This gene has 42 transcripts (splice variants), 278 orthologues and 20 paralogues. Ubiquitous expression in brain (RPKM 25.3), lymph node (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

DNAJC7 Products (2)

mRNA Protein Name
NM_001144766.3 NP_001138238.1 dnaJ homolog subfamily C member 7 isoform 2
NM_003315.4 NP_003306.3 dnaJ homolog subfamily C member 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
12853476 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17043677 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in chaperone cofactor-dependent protein refolding IDA
IDA: Inferred from direct assay
12853476 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
12853476 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC7 Protein Structure

TPR_11

TPR_11: TPR repeat (27 - 92)

TPR_9

TPR_9: Tetratricopeptide repeat (154 - 203)

TPR_1

TPR_1: Tetratricopeptide repeat (210 - 243)

TPR_11

TPR_11: TPR repeat (258 - 324)

TPR_1

TPR_1: Tetratricopeptide repeat (329 - 354)

DnaJ

DnaJ: DnaJ domain (381 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily C member 7

  • DnaJ (Hsp40) homolog, subfamily C, member 7

DNAJC7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
DNAJC7 Q99615 BAG4 Homo sapiens O95429
Anti Tag CoIP
35271311
Intra
DNAJC7 Q99615 BAG2 Homo sapiens O95816
Lumier
25036637
Intra
DNAJC7 Q99615 BAG2 Homo sapiens O95816
Anti Tag CoIP
26496610
Intra
DNAJC7 Q99615 BAG2 Homo sapiens O95816
Anti Tag CoIP
35271311
Intra
DNAJC7 Q99615 DISC1 Homo sapiens Q9NRI5
Y2H
17043677
Cross: Cross-species interaction Intra: Intraspecies interaction

DNAJC7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P810529 DnaJC7 Antibody (YA9800) WB, FC human, mouse, rat
HY-P810530 DnaJC7 Antibody WB, IHC-P Human, Mouse

関連疾患

Diseases Alias
Fatal Infantile Hypertonic Myofibrillar Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03888 DNAJC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus DNAJC7 VGNC VGNC:98904
Canis familiaris DNAJC7 VGNC VGNC:55643
Bos taurus DNAJC7 VGNC VGNC:55817
Macaca mulatta DNAJC7 VGNC VGNC:99144
Rattus norvegicus DNAJC7 RGD RGD:1303226
Mus musculus DNAJC7 MGD MGI:1928373
Others DNAJC7 NCBI