ZBTB17 - zinc finger and BTB domain containing 17 Gene

Also Known as MIZ-1; ZNF60; ZNF151; pHZ-67

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7709

About ZBTB17

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:15,941,869-15,976,101 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 51 paralogues. Ubiquitous expression in bone marrow (RPKM 10.4), testis (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a Zinc Finger Protein involved in the regulation of c-Myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

ZBTB17 Products (6)

mRNA Protein Name
NM_001242884.2 NP_001229813.1 zinc finger and BTB domain-containing protein 17 isoform 1
NM_001287603.2 NP_001274532.1 zinc finger and BTB domain-containing protein 17 isoform 3
NM_001287604.2 NP_001274533.1 zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324137.2 NP_001311066.1 zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324138.2 NP_001311067.1 zinc finger and BTB domain-containing protein 17 isoform 5
NM_003443.3 NP_003434.2 zinc finger and BTB domain-containing protein 17 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9312026 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
9312026 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12244100 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19160485 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
9312026 GOA
enables core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19160485 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9308237 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
19160485 GOA
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of negative effect G1 to G0 transition IDA
IDA: Inferred from direct assay
19160485 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19160485 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9312026 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19160485 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of protein-DNA complex IMP
IMP: Inferred from mutant phenotype
19160485 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
19160485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB17 Protein Structure

BTB

BTB: BTB/POZ domain (14 - 110)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (320 - 344)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (377 - 401)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (404 - 428)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (446 - 456)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (460 - 485)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (488 - 512)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (516 - 540)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (545 - 568)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (573 - 597)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (600 - 624)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (717 - 739)

  • 0
  • 200
  • 400
  • 600
  • 803 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 17

  • Myc-interacting Zn finger protein-1

ZBTB17 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ZBTB17 Q13105 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
ZBTB17 Q13105 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
ZBTB17 Q13105 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
ZBTB17 Q13105 TOPBP1 Homo sapiens Q92547
Anti Bait CoIP
18923429
Intra
ZBTB17 Q13105 HCFC1 Homo sapiens P51610
CoIP
12244100
Intra
ZBTB17 Q13105 HCFC1 Homo sapiens P51610
Y2H
12244100
Intra
ZBTB17 Q13105 HCFC1 Homo sapiens P51610
Pull Down
12244100
Intra
ZBTB17 Q13105 MYC Homo sapiens P01106
Anti Bait CoIP
26766587
Intra
ZBTB17 Q13105 MYC Homo sapiens P01106
Pull Down
26766587
Intra
ZBTB17 Q13105 MYC Homo sapiens P01106
Anti Bait CoIP
18923429
Intra
ZBTB17 Q13105 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
ZBTB17 Q13105 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
ZBTB17 Q13105 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
ZBTB17 Q13105 MAGEA4 Homo sapiens P43358
Anti Tag CoIP
14739298
Intra
ZBTB17 Q13105 MAGEA4 Homo sapiens P43358
Y2H
14739298
Intra
ZBTB17 Q13105 MAGEA4 Homo sapiens P43358
Confocal
14739298
Intra
ZBTB17 Q13105 MYCN Homo sapiens P04198
Pull Down
26766587
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZBTB17 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71437 ZBTB17 Protein, Human (His) Q13105 (M1-A188) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15965 ZBTB17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21220 Zbtb17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27736 Zbtb17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris ZBTB17 VGNC VGNC:48525
Mus musculus ZBTB17 MGD MGI:107410
Rattus norvegicus ZBTB17 RGD RGD:1307143
Bos taurus ZBTB17 VGNC VGNC:52849
Macaca mulatta ZBTB17 VGNC VGNC:78849
Felis catus ZBTB17 VGNC VGNC:67163
Others ZBTB17 NCBI