TCL1A - TCL1 family AKT coactivator A Gene

Also Known as TCL1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8115

About TCL1A

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:95,709,947-95,714,125 (from NCBI)

This gene has 9 transcripts (splice variants), 106 orthologues, 2 paralogues and is associated with 45 phenotypes. Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues.

Summary

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase Akt (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

TCL1A Products (2)

mRNA Protein Name
NM_001098725.2 NP_001092195.1 T-cell leukemia/lymphoma protein 1A
NM_021966.3 NP_068801.1 T-cell leukemia/lymphoma protein 1A
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IDA
IDA: Inferred from direct assay
10983986 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
10983986 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
10983986 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
10983986 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10983986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCL1A Protein Structure

TCL1_MTCP1

TCL1_MTCP1: TCL1/MTCP1 family (1 - 112)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

T-cell leukemia/lymphoma protein 1A

  • T cell leukemia/lymphoma 1A

TCL1A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TCL1A P56279 TP53BP2 Homo sapiens Q13625-3 25416956
Intra
TCL1A P56279 TP53BP2 Homo sapiens Q13625-3 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 32296183
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 25416956
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 32296183
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 25416956
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 TNKS Homo sapiens O95271 32296183
Intra
TCL1A P56279 TNKS Homo sapiens O95271 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 TTC33 Homo sapiens Q6PID6 32296183
Intra
TCL1A P56279 TTC33 Homo sapiens Q6PID6 25416956
Intra
TCL1A P56279 NFKBIA Homo sapiens P25963 32296183
Intra
TCL1A P56279 NFKBIA Homo sapiens P25963 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 25416956
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 25416956
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 25416956
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 27107012
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 25416956
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 33961781
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TCF4 Homo sapiens P15884 25416956
Intra
TCL1A P56279 TCF4 Homo sapiens P15884 25416956
Intra
TCL1A P56279 TXLNB Homo sapiens Q8N3L3 25416956
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 27107012
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 25416956
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 WDR47 Homo sapiens O94967 25416956
Intra
TCL1A P56279 WDR47 Homo sapiens O94967 25416956
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 25416956
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 33961781
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 31515488
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 16189514
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 25416956
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 25416956
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4
Y2H
27107012
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 25416956
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 27107012
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 31515488
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 25416956
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 25416956
Intra
TCL1A P56279 FLACC1 Homo sapiens Q96Q35 25416956
Intra
TCL1A P56279 FLACC1 Homo sapiens Q96Q35 25416956
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257 25416956
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257 25416956
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 33961781
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TCL1A Proteins

製品番号 製品名 アクセッション番号 純度
HY-P74530 TCL1A Protein, Human (His) P56279 (A2-D114) ≥ 85%, as determined by reducing SDS-PAGE.

TCL1A 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81959 T Cell Leukemia/Lymphoma Protein 1A Antibody (YA1704) WB, IHC-P, ICC/IF, FC Human
HY-P85928 T Cell Leukemia/Lymphoma Protein 1A Antibody (YA5620) IHC-P, WB, ICC/IF, ELISA Human

関連疾患

Diseases Alias
Precursor T-Cell Acute Lymphoblastic Leukemia
  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia

Leukemia
  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos

Prolymphocytic Leukemia
  • Pll

  • Prolymphocytic Leukaemia

  • Leukemia Prolymphocytic

  • Leukemia, Prolymphocytic

Lymphoma
  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos

T-Cell Prolymphocytic Leukemia
  • T Cell Prolymphocytic Leukemia

  • Prolymphocytic Leukemia, T-Cell Type

  • T-Pll

  • T-Cell Chronic Lymphocytic Leukemia

  • Lymphocytic Leukemia T-Cell Chronic

  • Doid:0081042

  • Leukemia, T-Cell, Chronic

  • Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Peripheral T-Cell Lymphoma
  • Lymphoma T-Cell Peripheral

Lymphoma Aids Related
  • Primary Effusion Lymphoma

  • Lymphoma, Aids-Related

  • Aids-Related Lymphoma

  • Pel

  • Aids Related Lymphoma

  • Body Cavity-Based Lymphoma

  • Lymphoma Aids-Related

Burkitt Lymphoma
  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma

Seminoma
  • Seminoma, Pure

Ataxia-Telangiectasia
  • Ataxia Telangiectasia

  • Louis-Bar Syndrome

  • AT

  • At1

  • Ataxia-Telangiectasia Syndrome

  • Ataxia - Telangiectasia Variant

  • Boder-Sedgwick Syndrome

  • Louis Bar Syndrome

  • Cerebello-Oculocutaneous Telangiectasia

  • Immunodeficiency With Ataxia Telangiectasia

  • A-T

  • Ataxia Telangiectasia Syndrome

  • Atm

  • Telangiectasia, Cerebello-Oculocutaneous

  • Ataxia-Telangiectasia Variant

T-Cell Acute Lymphoblastic Leukemia
  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

B-Cell Lymphoma
  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos

Bn2 Diffuse Large B-Cell Lymphoma
  • Bn2 Dlbcl

  • Doid:0081064

Lymphoproliferative Syndrome
  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To

Leukemia, Chronic Lymphocytic
  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell

Richter'S Syndrome
  • Richter Syndrome

  • Richter Transformation

Lymphoma, Non-Hodgkin, Familial
  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma

Follicular Lymphoma
  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma

Mantle Cell Lymphoma
  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma

Myeloma, Multiple
  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]

Leukemia, Acute Lymphoblastic
  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus TCL1A MGD MGI:1097166
Rattus norvegicus TCL1A RGD RGD:1594686
Bos taurus TCL1A VGNC VGNC:99734
Others TCL1A NCBI