BRAP - BRCA1 associated protein Gene

Also Known as IMP; BRAP2; RNF52

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 8315

About BRAP

Cytogenetic location: 12q24.12 Genomic coordinates (GRCh38): 12:111,642,146-111,685,956 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 24.8), bone marrow (RPKM 8.8) and 24 other tissues.

Summary

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and Other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

BRAP Products (1)

mRNA	Protein	Name
NM_006768.5	NP_006759.3	BRCA1-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables identical protein binding	IPI IPI: Inferred from physical interaction	14724641	GOA
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	9497340	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9497340	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14724641	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14724641	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	14724641	GOA
acts upstream of or within Ras protein signal transduction	IDA IDA: Inferred from direct assay	14724641	GOA
involved in negative regulation of signal transduction	IDA IDA: Inferred from direct assay	14724641	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14724641	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	9497340	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14724641	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRAP Protein Structure

BRAP2

zf-RING_2

zf-UBP

0
100
200
300
400
500
592 a.a.

Protein Preferred Names	Protein Names
BRCA1-associated protein	RING finger protein 52

BRAP Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	BRAP	Q7Z569	YJU2	Homo sapiens	Q9BW85	Validated Y2H	32296183
Intra	BRAP	Q7Z569	HRAS	Homo sapiens	P01112	CoIP	14724641
Intra	BRAP	Q7Z569	BRAP	Homo sapiens	Q7Z569	CoIP	14724641
Intra	BRAP	Q7Z569	BRCA1	Homo sapiens	P38398	Pull Down	9497340
Intra	BRAP	Q7Z569	PHLPP1	Homo sapiens	O60346	Y2H	25820252
Intra	BRAP	Q7Z569	HRAS	Homo sapiens	P01112	Pull Down	14724641
Intra	BRAP	Q7Z569	EFHC1	Homo sapiens	Q5JVL4	Y2H	25820252
Intra	BRAP	Q7Z569	AKAP3	Homo sapiens	O75969	Anti Tag CoIP	25820252
Intra	BRAP	Q7Z569	KSR1	Homo sapiens	Q8IVT5	CoIP	14724641
Intra	BRAP	Q7Z569	AKAP3	Homo sapiens	O75969	Y2H	25820252
Intra	BRAP	Q7Z569	Dnmt1	Mus musculus	P13864	Anti Tag CoIP	25820252
Intra	BRAP	Q7Z569	BRAP	Homo sapiens	Q7Z569	Y2H	25820252

Cross: Cross-species interaction Intra: Intraspecies interaction

BRAP 抗体

製品番号	製品名	アプリケーション	反応性
HY-P85593	BRAP Antibody (YA5285)	WB	Human

Diseases	Alias
Astereognosia	Somatosensory Agnosia Tactile Agnosia
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS01591	BRAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18746	Brap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25233	Brap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	BRAP	RGD	RGD:1586551
Bos taurus	BRAP	VGNC	VGNC:26552
Mus musculus	BRAP	MGD	MGI:1919649
Canis familiaris	BRAP	VGNC	VGNC:38515
Felis catus	BRAP	VGNC	VGNC:60163
Macaca mulatta	BRAP	VGNC	VGNC:70278
Others	BRAP	NCBI