PARG - poly(ADP-ribose) glycohydrolase Gene

Also Known as PARG99

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 8505

About PARG

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:49,818,279-49,942,027 (from NCBI)

This gene has 7 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 6.1) and 25 other tissues.

Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

PARG Products (15)

mRNA	Protein	Name
XR_007062014.1
XM_047425921.1	XP_047281877.1	poly(ADP-ribose) glycohydrolase isoform X2
NR_136756.3
NM_001324381.3	NP_001311310.1	poly(ADP-ribose) glycohydrolase isoform b
NM_001303486.3	NP_001290415.1	poly(ADP-ribose) glycohydrolase isoform b
NM_001303487.3	NP_001290416.1	poly(ADP-ribose) glycohydrolase isoform c
NR_130169.3
NR_130168.3
NM_001303489.3	NP_001290418.1	poly(ADP-ribose) glycohydrolase isoform d
NR_136755.3
NM_003631.5	NP_003622.2	poly(ADP-ribose) glycohydrolase isoform a
XM_011540305.2	XP_011538607.1	poly(ADP-ribose) glycohydrolase isoform X1
NR_136752.3
NR_136753.3
NR_136754.3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables poly(ADP-ribose) glycohydrolase activity	IDA IDA: Inferred from direct assay	9074616	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27257257	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in ATP generation from poly-ADP-D-ribose	IDA IDA: Inferred from direct assay	27257257	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in nucleus	IDA IDA: Inferred from direct assay	9074616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARG Protein Structure

PARG_cat

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
poly(ADP-ribose) glycohydrolase	mitochondrial poly(ADP-ribose) glycohydrolase

Diseases	Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures	CONDSIAS Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-B0889	Ethacridine lactate monohydrate	Inhibitor	99.85%	Unkown
HY-B2174	Ethacridine lactate	Inhibitor	99.83%	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P99965	Crovalimab	Inhibitor	99.59%	Unkown

Clinical Phase