PER2 - period circadian regulator 2 Gene
Also Known as FASPS; FASPS1
生物種: Homo sapiens
About PER2
This gene has 4 transcripts (splice variants), 254 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 8.7), gall bladder (RPKM 7.6) and 25 other tissues.
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
PER2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_022817.3 | NP_073728.1 | period circadian protein homolog 2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16790549 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
22274616 | GOA |
PER2 Protein Structure
PAS_11: PAS domain (333 - 434)
Period_C: Period protein 2/3C-terminal region (1046 - 1234)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1200
- 1255 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
period circadian protein homolog 2 |
|
PER2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
PER2 | O15055 | LMO4 | Homo sapiens | P61968 | 32296183 | |
|
Intra
|
PER2 | O15055 | UBL4A | Homo sapiens | P11441 | 32296183 | |
|
Intra
|
PER2 | O15055 | LENG8 | Homo sapiens | Q96PV6 | 32296183 | |
|
Intra
|
PER2 | O15055 | ELOA | Homo sapiens | Q14241 | 32296183 | |
|
Intra
|
PER2 | O15055 | MLH1 | Homo sapiens | P40692 | 32296183 | |
|
Intra
|
PER2 | O15055 | CSNK1E | Homo sapiens | P49674 | 32296183 | |
|
Intra
|
PER2 | O15055 | CSNK1D | Homo sapiens | P48730 | 32296183 |
PER2 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P82608 | PER2 Antibody (YA2353) | WB, ICC/IF, FC | Human |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Advanced Sleep Phase Syndrome, Familial, 1 |
|
|
| Advanced Sleep Phase Syndrome |
|
|
| Delayed Sleep Phase Disorder |
|
|
| Rem Sleep Behavior Disorder |
|
|
| Q Fever |
|
|
| Sleep Disorder |
|
|
| Major Depressive Disorder |
|
|
| Bipolar Disorder |
|
|
| Periodic Limb Movement Disorder |
|
|
| Autism Spectrum Disorder |
|
|
| Autism |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Macaca mulatta | PER2 | VGNC | VGNC:75943 |
| Rattus norvegicus | PER2 | RGD | RGD:61945 |
| Felis catus | PER2 | VGNC | VGNC:107597 |
| Bos taurus | PER2 | VGNC | VGNC:106859 |
| Mus musculus | PER2 | MGD | MGI:1195265 |
| Canis familiaris | PER2 | VGNC | VGNC:44421 |
| Others | PER2 | NCBI |