POM121 - POM121 transmembrane nucleoporin Gene
Also Known as P145; POM121A
生物種: Homo sapiens
遺伝子タイプ: protein coding
遺伝子ID: 9883
About POM121
Cytogenetic location: 7q11.23
Genomic coordinates (GRCh38): 7:72,879,357-72,951,459 (from NCBI)
This gene has 3 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.
Summary
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
POM121 Products (23)
| mRNA | Protein | Name |
|---|---|---|
| NM_001257190.3 | NP_001244119.1 | nuclear envelope pore membrane protein POM 121 isoform 1 |
| NM_001367610.1 | NP_001354539.1 | nuclear envelope pore membrane protein POM 121 isoform 3 |
| NM_001387685.1 | NP_001374614.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387686.1 | NP_001374615.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387687.1 | NP_001374616.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387688.1 | NP_001374617.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387689.1 | NP_001374618.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387691.1 | NP_001374620.1 | nuclear envelope pore membrane protein POM 121 isoform 4 |
| NM_001387692.1 | NP_001374621.1 | nuclear envelope pore membrane protein POM 121 isoform 5 |
| NM_001387693.1 | NP_001374622.1 | nuclear envelope pore membrane protein POM 121 isoform 6 |
| NM_001387694.1 | NP_001374623.1 | nuclear envelope pore membrane protein POM 121 isoform 7 |
| NM_001387695.1 | NP_001374624.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387696.1 | NP_001374625.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387697.1 | NP_001374626.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387698.1 | NP_001374627.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387699.1 | NP_001374628.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387700.1 | NP_001374629.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| NM_001387701.1 | NP_001374630.1 | nuclear envelope pore membrane protein POM 121 isoform 3 |
| NM_001387702.1 | NP_001374631.1 | nuclear envelope pore membrane protein POM 121 isoform 3 |
| NM_001387703.1 | NP_001374632.1 | nuclear envelope pore membrane protein POM 121 isoform 3 |
| NM_001387704.1 | NP_001374633.1 | nuclear envelope pore membrane protein POM 121 isoform 3 |
| NM_001387705.1 | NP_001374634.1 | nuclear envelope pore membrane protein POM 121 isoform 8 |
| NM_172020.5 | NP_742017.1 | nuclear envelope pore membrane protein POM 121 isoform 2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in nuclear envelope |
IDA
IDA: Inferred from direct assay
|
24315095 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
POM121 Protein Structure
POM121
POM121: POM121 family (316 - 553)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1249 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nuclear envelope pore membrane protein POM 121 |
|
POM121 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
POM121 | Q96HA1 | PAXIP1 | Homo sapiens | Q6ZW49-2 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | AGR2 | Homo sapiens | O95994 | 16189514 | |
|
Intra
|
POM121 | Q96HA1 | RBPMS | Homo sapiens | Q93062 | 16189514 | |
|
Intra
|
POM121 | Q96HA1 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | FXR2 | Homo sapiens | P51116 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | TEX11 | Homo sapiens | Q8IYF3 | 16189514 | |
|
Intra
|
POM121 | Q96HA1 | TEX11 | Homo sapiens | Q8IYF3 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | HOMER3 | Homo sapiens | Q9NSC5 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | HOMER3 | Homo sapiens | Q9NSC5 | 25416956 | |
|
Intra
|
POM121 | Q96HA1 | HOMER3 | Homo sapiens | Q9NSC5 | 25416956 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
関連疾患
| Diseases | Alias | |
|---|---|---|
| Acute Dacryocystitis |
|
|
| Trachea Adenoid Cystic Carcinoma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| 製品番号 | 製品名 |
製品効果
|
純度 |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS10864 | POM121 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | POM121 | MGD | MGI:2137624 |
| Rattus norvegicus | POM121 | RGD | RGD:620680 |
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