HC-7366
Based on 1 Customer Validation
HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.58%
- CAS 番号: 2803470-63-3
- 分子式: C20H15ClF2N6O4S
- 分子量:508.89
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
HC-7366 (0.1 nM-0.1 μM, 72 h) significantly inhibited the proliferation of MOLM-16 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT1080 and MOLM-16 xenograft models established in female BALB/c nude mice[1]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:Oral administration (p.o.), twice daily for 17 or 31 days
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Result:Demonstrated potent tumor growth inhibition.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2803470-63-3
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性状 Solid
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分子量 508.89
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分子式 C20H15ClF2N6O4S
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Color White to off-white
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SMILES
O=C(C1=C2C=NC(C3=C(C=CC(NS(=O)(C4=CC(Cl)=CN=C4OC)=O)=C3F)F)=CN2C=N1)NC
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別名
GCN2 modulator-1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 31.25 mg/mL (61.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9651 mL | 9.8253 mL | 19.6506 mL | 49.1265 mL |
| 5 mM | 0.3930 mL | 1.9651 mL | 3.9301 mL | 9.8253 mL | |
| 10 mM | 0.1965 mL | 0.9825 mL | 1.9651 mL | 4.9127 mL | |
| 15 mM | 0.1310 mL | 0.6550 mL | 1.3100 mL | 3.2751 mL | |
| 20 mM | 0.0983 mL | 0.4913 mL | 0.9825 mL | 2.4563 mL | |
| 25 mM | 0.0786 mL | 0.3930 mL | 0.7860 mL | 1.9651 mL | |
| 30 mM | 0.0655 mL | 0.3275 mL | 0.6550 mL | 1.6376 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4913 mL | 1.2282 mL | |
| 50 mM | 0.0393 mL | 0.1965 mL | 0.3930 mL | 0.9825 mL | |
| 60 mM | 0.0328 mL | 0.1638 mL | 0.3275 mL | 0.8188 mL |
HC-7366 関連分類
HY-160196 関連分類
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