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製品番号: HY-189682

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HS-10375

HS-10375 is a selective EGFR tyrosine kinase inhibitor. HS-10375 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in an ATP-competitive manner, with IC₅₀ values of 0.09 nM and 0.08 nM, respectively. HS-10375 exhibits higher inhibitory activity against the proliferation of mutant EGFR cells than wild-type EGFR cells, demonstrating selectivity for mutant EGFR and potentially reducing off-target effects. HS-10375 can be used in research related to non-small cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2567456-79-3
分子式: C₃₃H₄₂BrN₆O₅P
分子量:713.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HS-10375 構造式

CAS 番号: 2567456-79-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

EGFR-19del/T790M/C797S-TK 和，IC50 值分别为 nM 和。

0.09 nM (IC₅₀)

EGFR-L858R/T790M/C797S-TK

0.08 nM nM (IC₅₀)

EGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC50	138 nM	Inhibitory activity against A431 cells expressing wild-type EGFR assessed as IC50 by cell-based assay. Inhibitory activity against A431 cells expressing wild-type EGFR assessed as IC50 by cell-based assay.	42603542

体外実験

HS-10375 inhibits the proliferation of Ba/F3-EGFR-19del/T790M/C797S-TK and A431 cells with IC₅₀ values of 23 nM and 138 nM, respectively, demonstrating selectivity for mutant EGFR and reducing potential off-target effects^[1].
HS-10375 exhibits significant inhibitory activity against mutant EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK, with in vitro enzymatic assay IC₅₀ values of 0.09 nM and 0.08 nM, respectively, and an IC₅₀ of 23 nM against wild-type EGFR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

化学情報

CAS 番号 2567456-79-3
分子量 713.60
分子式 C₃₃H₄₂BrN₆O₅P
SMILES

[H][C@]12[C@@]([H])(CN(C(CC3)CCN3C(C=C4OC)=C(C)C=C4NC5=NC=C(Br)C(NC6=CC=C7OCCOC7=C6P(C)(C)=O)=N5)C2)COC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kadam VM, et al. Recent advances in synthetic strategies of fourth-generation EGFR tyrosine kinase inhibitors under clinical trials for the treatment of resistant non-small cell lung cancer (NSCLC). Bioorganic chemistry. 2026 Oct 05;181:110353.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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