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製品番号: HY-139052

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III-31-C

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC₅₀ of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research.

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CAS 番号: 398515-96-3
分子式: C₃₅H₅₂N₄O₇
分子量:640.81

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

III-31-C 構造式

CAS 番号: 398515-96-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.22 μM Compound: 15	Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)	[PMID: 15050631]
CHO	IC₅₀	0.4 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA	[PMID: 15588083]
CHO	IC₅₀	0.4 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP by ELISA Inhibition of gamma secretase in CHO cells expressing human APP by ELISA	[PMID: 15588083]
CHO	IC₅₀	18 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA	[PMID: 15588083]
HeLa	IC₅₀	0.01 μM Compound: 31c	Inhibition of gamma secretase isolated from HeLa cells by ELISA Inhibition of gamma secretase isolated from HeLa cells by ELISA	[PMID: 15588083]

化学情報

CAS 番号 398515-96-3
分子量 640.81
分子式 C₃₅H₅₂N₄O₇
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(OC)=O)=O)N(C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)CC2=CC=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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