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製品番号: HY-184213

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INCB106385

INCB106385 is an orally active A₂A/A₂B adenosine receptor antagonist, with an IC₅₀ value of 4.4 nM for cAMP inhibition at the A₂A adenosine receptor and an IC₅₀ value of 6.4 nM for cAMP inhibition at the A₂B adenosine receptor. INCB106385 inhibits the pCREB signaling pathway in immune cells, blocks adenosine-mediated immunosuppression in the tumor microenvironment, and induces tumor regression. INCB106385 exhibits efficacy as a monotherapy or in combination with anti-PD-1 antibodies in colon cancer models. INCB106385 can be used for the research of colon cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2408260-34-2
分子式: C₂₃H₁₇N₉O
分子量:435.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

INCB106385 構造式

CAS 番号: 2408260-34-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- Parmacokinetics
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

A2AR

A2BR

Adenosine Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

INCB106385 (compound 36) inhibits cAMP production in A₂A-overexpressing HEK293 cells with an IC₅₀ of 4.4 nM^[1].
INCB106385 inhibits cAMP production in A₂B-overexpressing HEK293 cells with an IC₅₀ of 6.4 nM^[1].
INCB106385 inhibits phospho-CREB levels in human whole blood CD4⁺ T cells with an IC₅₀ of 4.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC	Bioavailability
Rat^[1]	1.0 mg/kg	i.v.	8.7 h	/	27300 nM·h	/
Rat^[1]	3.0 mg/kg	p.o.	/	18200 nM	27300 nM·h	108 %
Cynomolgus Monkey^[1]	1.0 mg/kg	i.v.	5.8 h	/	/	/
Cynomolgus Monkey^[1]	3.0 mg/kg	p.o.	/	3870 nM	12500 nM·h	80 %

化学情報

CAS 番号 2408260-34-2
分子量 435.44
分子式 C₂₃H₁₇N₉O
SMILES

N#CC1=CC=CC(C2=C(C(C=C3)=NN(C)C3=O)N4C(C(N)=N2)=NC(CC5=NC=CC=C5)=N4)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Qi C, et al. Discovery of Dual A2A/A2B Adenosine Receptor Antagonist and Clinical Candidate INCB106385. J Med Chem. 2026 Jun 11;69(11):13899-13918. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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