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製品番号: HY-187709

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Indolaprilat

Indolaprilat is an ACE inhibitor with an IC₅₀ value of 3.0 nM. Indolaprilat also inhibits aminopeptidase P, with an IC₅₀ of 485 μM for aminopeptidase P. Indolaprilat inhibits the zinc metallopeptidase-mediated cleavage of angiotensin I, Bradykinin (HY-P0206), and proline-containing oligopeptides. Indolaprilat can be used in related research on hypertension and congestive heart failure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 80828-34-8
分子式: C₂₂H₃₀N₂O₅
分子量:402.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Indolaprilat 構造式

CAS 番号: 80828-34-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

ACE

3 nM (IC₅₀)

aminopeptidase P

485 μM (IC₅₀)

Aminopeptidase アイソフォーム固有の製品をすべて表示 :

CD13
LTA4H

体外実験

Indolaprilat (1 mM; 5 min) inhibits purified porcine renal cortical aminopeptidase P with an IC₅₀ of 485 μM, and also inhibits purified porcine renal angiotensin-converting enzyme with an IC₅₀ of 3.0 nM^[1].
Indolaprilat exhibits potent angiotensin-converting enzyme (ACE) inhibitory activity in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 80828-34-8
分子量 402.48
分子式 C₂₂H₃₀N₂O₅
SMILES

OC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@]3([H])[C@](CCCC3)([H])C[C@H]2C(O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hooper NM, et al. Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P. Hypertension (Dallas, Tex. : 1979). 1992 Mar;19(3):281-5.

[2]. Blankley CJ, et al. Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. J Med Chem. 1987 Jun;30(6):992-8.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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