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製品番号: HY-124605

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IQS-019

IQS-019 is a B cell receptor (BCR) kinase inhibitor. IQS-019 can inhibit the de-phosphorylation of constitutive and IgM-activated Syk, Lyn, and Btk. IQS-019 can inhibit cell proliferation, migration and induce apoptosis. IQS-019 exhibits antitumor activity and can be used for the research of cancer, such as B cell lymphoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1630804-24-8
分子式: C₂₅H₂₅Cl₂N₇O
分子量:510.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IQS-019 構造式

CAS 番号: 1630804-24-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	GI₅₀	2.7 μM Compound: 19	Growth inhibition of human DOHH2 cells after 48 hrs by MTT assay Growth inhibition of human DOHH2 cells after 48 hrs by MTT assay	[PMID: 25222877]
DOHH-2	GI₅₀	3.7 μM Compound: 19	Growth inhibition of human DOHH2 cells after 24 hrs by MTT assay Growth inhibition of human DOHH2 cells after 24 hrs by MTT assay	[PMID: 25222877]
Granta-519	GI₅₀	3 μM Compound: 19	Growth inhibition of human GRANTA-519 cells after 48 hrs by MTT assay Growth inhibition of human GRANTA-519 cells after 48 hrs by MTT assay	[PMID: 25222877]
Granta-519	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human GRANTA-519 cells after 24 hrs by MTT assay Growth inhibition of human GRANTA-519 cells after 24 hrs by MTT assay	[PMID: 25222877]
JeKo-1	GI₅₀	3 μM Compound: 19	Growth inhibition of human JeKo1 cells after 48 hrs by MTT assay Growth inhibition of human JeKo1 cells after 48 hrs by MTT assay	[PMID: 25222877]
JeKo-1	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human JeKo1 cells after 24 hrs by MTT assay Growth inhibition of human JeKo1 cells after 24 hrs by MTT assay	[PMID: 25222877]
JVM-2	GI₅₀	3 μM Compound: 19	Growth inhibition of human JVM2 cells after 48 hrs by MTT assay Growth inhibition of human JVM2 cells after 48 hrs by MTT assay	[PMID: 25222877]
JVM-2	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human JVM2 cells after 24 hrs by MTT assay Growth inhibition of human JVM2 cells after 24 hrs by MTT assay	[PMID: 25222877]
Maver1	GI₅₀	3 μM Compound: 19	Growth inhibition of human Maver1 cells after 48 hrs by MTT assay Growth inhibition of human Maver1 cells after 48 hrs by MTT assay	[PMID: 25222877]
Maver1	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human Maver1 cells after 24 hrs by MTT assay Growth inhibition of human Maver1 cells after 24 hrs by MTT assay	[PMID: 25222877]
Rec1	GI₅₀	3 μM Compound: 19	Growth inhibition of human Rec1 cells after 48 hrs by MTT assay Growth inhibition of human Rec1 cells after 48 hrs by MTT assay	[PMID: 25222877]
Rec1	GI₅₀	3.2 μM Compound: 19	Growth inhibition of human Rec1 cells after 24 hrs by MTT assay Growth inhibition of human Rec1 cells after 24 hrs by MTT assay	[PMID: 25222877]
SU-DHL-16	GI₅₀	5 μM Compound: 19	Growth inhibition of human SUDHL16 cells after 48 hrs by MTT assay Growth inhibition of human SUDHL16 cells after 48 hrs by MTT assay	[PMID: 25222877]
SU-DHL-16	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human SUDHL16 cells after 24 hrs by MTT assay Growth inhibition of human SUDHL16 cells after 24 hrs by MTT assay	[PMID: 25222877]
SU-DHL-8	GI₅₀	5 μM Compound: 19	Growth inhibition of human SUDHL8 cells after 48 hrs by MTT assay Growth inhibition of human SUDHL8 cells after 48 hrs by MTT assay	[PMID: 25222877]
SU-DHL-8	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human SUDHL8 cells after 24 hrs by MTT assay Growth inhibition of human SUDHL8 cells after 24 hrs by MTT assay	[PMID: 25222877]
U2932	GI₅₀	5 μM Compound: 19	Growth inhibition of human U2932 cells after 48 hrs by MTT assay Growth inhibition of human U2932 cells after 48 hrs by MTT assay	[PMID: 25222877]
U2932	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human U2932 cells after 24 hrs by MTT assay Growth inhibition of human U2932 cells after 24 hrs by MTT assay	[PMID: 25222877]
WSU-NHL	GI₅₀	2.7 μM Compound: 19	Growth inhibition of human WSU-NHL cells after 48 hrs by MTT assay Growth inhibition of human WSU-NHL cells after 48 hrs by MTT assay	[PMID: 25222877]
WSU-NHL	GI₅₀	3.7 μM Compound: 19	Growth inhibition of human WSU-NHL cells after 24 hrs by MTT assay Growth inhibition of human WSU-NHL cells after 24 hrs by MTT assay	[PMID: 25222877]

化学情報

CAS 番号 1630804-24-8
分子量 510.42
分子式 C₂₅H₂₅Cl₂N₇O
SMILES

O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=C(N)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N1C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Balsas P, et al. Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma. J Hematol Oncol. 2017 Mar 31;10(1):80. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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