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United States

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製品番号: HY-119118

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J-30

J-30 is an orally active and potent tubulin inhibitor (IC₅₀=15-20 nM). J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 916484-16-7
分子式: C₂₁H₁₉N₃O₄S
分子量:409.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

J-30 構造式

CAS 番号: 916484-16-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	8.6 nM Compound: 15, J-30	Cytotoxicity against human HT29 cell line by methylene blue dye assay Cytotoxicity against human HT29 cell line by methylene blue dye assay	[PMID: 17154496]
KB	IC₅₀	8.9 nM Compound: 15, J-30	Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay	[PMID: 17154496]
KB	IC₅₀	9.6 nM Compound: 15, J-30	Cytotoxicity against human KB cell line by methylene blue dye assay Cytotoxicity against human KB cell line by methylene blue dye assay	[PMID: 17154496]
MKN-45	IC₅₀	8.8 nM Compound: 15, J-30	Cytotoxicity against human MKN45 cell line by methylene blue dye assay Cytotoxicity against human MKN45 cell line by methylene blue dye assay	[PMID: 17154496]
NCI-H460	IC₅₀	9.4 nM Compound: 15, J-30	Cytotoxicity against human H460 cell line by methylene blue dye assay Cytotoxicity against human H460 cell line by methylene blue dye assay	[PMID: 17154496]
TSGH 9201	IC₅₀	10.8 nM Compound: 15, J-30	Cytotoxicity against human TSGH cell line by methylene blue dye assay Cytotoxicity against human TSGH cell line by methylene blue dye assay	[PMID: 17154496]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 916484-16-7
分子量 409.46
分子式 C₂₁H₁₉N₃O₄S
SMILES

O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323(1):398-405. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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