Jacaric acid
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator. Jacaric acid is orally active.
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- CAS 番号: 28872-28-8
- 分子式: C18H30O2
- 分子量:278.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Jacaric acid (0-10 μM) dose- and time-dependently induces apoptosis in cells PC-3 and LNCaP, through an intrinsic and an intrinsic and extrinsic pathway, respectively[1].
Jacaric acid (0-10 μM) induces cytotoxicity in DLD-1 cells through intracellular incorporation and induction of apoptosis via lipid peroxidation[2].
Jacaric acid (50-100 μM) activates the macrophage through secretion of cytokines IFN-γ, IL-1β and TNF-α, enhances the endocytic activity in murine peritoneal macrophages and induces the cytostatic activity in MBL-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, LNCaP
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Concentration:0-10 μM
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Incubation Time:24 h
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Result:Increased cleaved PARP and caspase 9 in PC-3 cells.
Increased cleaved PARP, caspase 8, caspase 9, p15 Bid and death receptor DR5 in LNCaP cells.
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Cell Line:PC-3, LNCaP, DLD-1
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Concentration:0-10 μM
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Incubation Time:24 h for cells PC-3 and LNCaP, 12 h for cell DLD-1
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Result:Induced apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DLD-1 xenograft athymic nude mice[2]
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Dosage:1 mg/mouse
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Administration:p.o. for 36 days
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Result:Reduced tumor volume without significant weight loss in body and liver.
化学情報
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CAS 番号 28872-28-8
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分子量 278.43
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分子式 C18H30O2
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SMILES
CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42.. [Content Brief]
[2]. Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8. [Content Brief]
[3]. Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Jacaric acid 関連分類
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