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製品番号: HY-14186

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KVI-020

Name: KVI-020
Brand: MedChemExpress
SKU: HY-14186
Availability: PreOrder

(別名: WYE-160020)

KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC₅₀ of 480 nM. KVI-020 can inhibits hERG, with an IC₅₀ of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1000306-34-2
分子式: C₂₀H₂₅N₃O₅S
分子量:419.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KVI-020 構造式

CAS 番号: 1000306-34-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

IC₅₀: 480 ± 44 nM (Kv1.5), 15100 nM (hERG)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>30 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	>30 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	1.41 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	2.66 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	23.4 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	3.87 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	480 nM Compound: 4g, KVI-020, WYE-160020	Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]

化学情報

CAS 番号 1000306-34-2
分子量 419.49
分子式 C₂₀H₂₅N₃O₅S
SMILES

O=C1N([C@@](C(C=C2)=CC=C2OC)([H])CN1N[S](C)(=O)=O)CCC(C=C3)=CC=C3OC
別名

WYE-160020
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Blass BE, et al. Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52(21):65 [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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