L-156602
L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 125228-51-5
- 分子式: C38H64N8O13
- 分子量:840.96
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
L-156602 (0.2-0.5 mg/kg, i.p.) suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation in PCI-induced inflammation of DBA/1 mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Dosage:0.1, 0.5 mg/kg, once daily for 3 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed the swelling completely after 4 h at 0.1 mg/kg, and the effect was still statistical after 24 h at 0.5 mg/kg.
Reduced the number of migrated leukocytes.
Suppressed the migration of neutrophils, macrophages and lymphocytes non-specifically.
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Animal Model:MDP-induced acute joint inflammation of BALB/c mice[1]
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Dosage:0.25, 0.5 mg/kg, once daily for 3 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed adjuvant arthritis although a slight reduction of body weight at the dose of 0.5 mg/kg after 24 h.
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Animal Model:0.5% PCI-induced inflammation of DBA/1 mice[2]
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Dosage:0.2, 0.5 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed ear swelling significantly and the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation.
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Animal Model:5% PCI-induced inflammation of DBA/1 mice[2]
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Dosage:0.4 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation non-specifically.
化学情報
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CAS 番号 125228-51-5
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分子量 840.96
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分子式 C38H64N8O13
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SMILES
CC[C@@H](C[C@H]1CC[C@@]([C@@](C(N[C@H]2[C@H](C(C)C)OC([C@@H](C)N(O)C([C@H]3CCCNN3C(CNC([C@H](C)N(O)C([C@@H]4CCCNN4C2=O)=O)=O)=O)=O)=O)=O)(O)C)(O)O[C@@H]1C)C
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別名
Antibiotic L 156602; PD 124966
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tsuji RF, et al. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6. [Content Brief]
[2]. Tsuji RF, et al. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L-156602 関連分類
HY-16384 関連分類
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