LAF-153
LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC50 values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the MetAP-2 cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 661482-39-9
- 分子式: C18H32N2O7
- 分子量:388.46
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
150 μM
Compound: 9c
|
Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
LAF-153 reversibly binds to human MetAP-2 via coordination of its hydroxyl groups to the enzyme's cobalt ions, with its t-butyl group and lactam ring occupying distinct pockets in the enzyme cleft[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 661482-39-9
-
分子量 388.46
-
分子式 C18H32N2O7
-
SMILES
CC(C)(C)/C=C/[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC)C(N[C@@H]1C(NC[C@@H](CC1)O)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LAF-153 関連分類
HY-183876 関連分類
Powered by Bioz