Laxogenin
Laxogenin ((25R)-3β-Hydroxy-5α-spirostan-6-one; 6-Oxotigogenin) is an orally active myostatin (myostatin) inhibitor. Laxogenin promotes myogenesis and enhances the formation and maturation of myotubes. Laxogenin downregulates ROS. When added to the culture medium for cultured meat production, Laxogenin improves the texture, quality and nutritional value of cultured meat. Laxogenin reduces the average number of tumors in a two-stage mouse lung carcinogenesis model. Laxogenin can be used in research related to myogenesis and lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1177-71-5
- 分子式: C27H42O4
- 分子量:430.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Laxogenin (10 nM) promotes the differentiation of bovine bone marrow mesenchymal stem cells (MSCs) through the following mechanisms: increasing creatine kinase activity by 11%, upregulating the expression of myogenic markers, downregulating the expression of myostatin (MSTN), reducing reactive oxygen species (ROS) levels by 18%, and increasing myotube size[1].
Laxogenin (10 nM) promotes the differentiation of porcine mesenchymal stem cells (MSCs) through the following mechanisms: increasing creatine kinase activity by up to 18%, upregulating the expression of myogenic markers, downregulating MSTN expression, and reducing ROS levels by 7%[1].
Laxogenin (10 nM) promotes the differentiation of chicken bone marrow mesenchymal stem cells (MSCs) through the following mechanisms: increasing creatine kinase activity by 9-12%, upregulating the expression of myogenic markers, reducing the expression of MSTN, and decreasing reactive oxygen species (ROS) levels by 37%[1].
Laxogenin (10 nM) promotes the differentiation of C2C12 cells by increasing myotube size, upregulating MYH protein expression, enhancing creatine kinase activity by 9-19%, and upregulating the expression of myogenic markers over a 6-day differentiation period[1].
Laxogenin (10 nM) inhibits the MSTN signaling pathway in C2C12 cells, reduces ROS levels by approximately 8%, and upregulates the expression of antioxidant factors to promote cell differentiation[1].
Laxogenin (Compound 3) (100 μg/mL; pre-incubated for 1 h prior to the addition of 32Pi/TPA, followed by 4 h of incubation) inhibits TPA-induced 32Pi incorporation into phospholipids of HeLa cells by 82.1%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1177-71-5
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分子量 430.63
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分子式 C27H42O4
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SMILES
C[C@@H]1[C@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@@](C(=O)C5)(C[C@@H](O)CC6)[H])[H])[H])[H])[H])[H])CC[C@@H](C)CO2
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別名
(25R)-3β-Hydroxy-5α-spirostan-6-one; 6-Oxotigogenin
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lim JH, et al. The Effects of Laxogenin and 5-Alpha-hydroxy-laxogenin on Myotube Formation and Maturation During Cultured Meat Production. Int J Mol Sci. 2025;26(1):345. Published 2025 Jan 2. [Content Brief]
[2]. Baba M, et al. Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. Biol Pharm Bull. 2000 May;23(5):660-2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Laxogenin 関連分類
HY-N2457 関連分類
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