Lemalesomab
Lemalesomab (IMMU-MN3) is a Fab' fragment of a murine anti-granulocyte monoclonal antibody targeting NCA-90 (CEACAM6). Lemalesomab binds strongly to NCA-90 on the surface of granulocytes, cross-reacts with epitopes of other CEA family members, and blocks the binding between human colon adenocarcinoma cells and CEA. When labeled with 99mTc, Lemalesomab can be used for radionuclide imaging of soft tissue infections and osteomyelitis.
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- CAS 番号: 250242-54-7
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human IgG1 kappa
Human
NCA-90
Pre-incubation of purified human neutrophils with Lemalesomab (20 μg/mL; 30 min) does not impair granulocyte functions (superoxide anion production, phagocytosis, chemotaxis, or MTT reduction), and a small but significant increase in MTT reduction is observed upon fMLP stimulation[1].
Lemalesomab inhibits the binding between the KM-12c human colon adenocarcinoma cell line and CEA by 80%-90%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
化学情報
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CAS 番号 250242-54-7
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SMILES
[Lemalesomab]
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別名
IMMU-MN3
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lemalesomab 関連分類
HY-P99691 関連分類
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