LW-216
LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2146090-18-6
- 分子式: C30H31NO5
- 分子量:485.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.1 μM
Compound: 18l
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Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| B16 | IC50 |
3.21 μM
Compound: 18l
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Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| HepG2 | IC50 |
4.66 μM
Compound: 18l
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Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| MCF7 | IC50 |
1.89 μM
Compound: 18l
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Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
体外実験
LW-216 (5-25 μM, 24 h) selectively downregulates TrxR1 protein levels and induce apoptosis in NCI-H460 and A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H460, A549
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Concentration:5, 15, 25 μM
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Incubation Time:24 h
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Result:Reduced TrxR1 expression in both cell lines.
Decreased the protein level of Bcl-2, PARP1 and Caspase-9, while increased Bax.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCI-H460 cells in a xenograft mice model[1]
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Dosage:8 mg/kg, once every two days for 18 days
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Administration:i.v.
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Result:Reduced bioluminescence intensity.
Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.
化学情報
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CAS 番号 2146090-18-6
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分子量 485.57
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分子式 C30H31NO5
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LW-216 関連分類
HY-163724 関連分類
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