MC-DM1
Based on 1 Customer Validation
MC-DM1 is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody agent conjugate (ADC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.50%
- CAS 番号: 1375089-56-7
- 分子式: C42H55ClN4O12
- 分子量:843.36
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
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Maytansinoids |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1375089-56-7
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性状 Solid
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分子量 843.36
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分子式 C42H55ClN4O12
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Color White to off-white
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SMILES
C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCCCCN(C4=O)C(C=C4)=O)=O)=O)[C@@]([C@@H]([C@](OC5=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N5)O)C)([H])O1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : ≥ 200 mg/mL (237.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (275 KB)
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SDS (698 KB)
- English - EN (698 KB)
- Français - FR (698 KB)
- Deutsch - DE (698 KB)
- Norwegian - NO (698 KB)
- Español - ES (698 KB)
- Swedish - SV (698 KB)
- Italian - IT (698 KB)
- Portuguese - PT (698 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1857 mL | 5.9287 mL | 11.8573 mL | 29.6433 mL |
| 5 mM | 0.2371 mL | 1.1857 mL | 2.3715 mL | 5.9287 mL | |
| 10 mM | 0.1186 mL | 0.5929 mL | 1.1857 mL | 2.9643 mL | |
| 15 mM | 0.0790 mL | 0.3952 mL | 0.7905 mL | 1.9762 mL | |
| 20 mM | 0.0593 mL | 0.2964 mL | 0.5929 mL | 1.4822 mL | |
| 25 mM | 0.0474 mL | 0.2371 mL | 0.4743 mL | 1.1857 mL | |
| 30 mM | 0.0395 mL | 0.1976 mL | 0.3952 mL | 0.9881 mL | |
| 40 mM | 0.0296 mL | 0.1482 mL | 0.2964 mL | 0.7411 mL | |
| 50 mM | 0.0237 mL | 0.1186 mL | 0.2371 mL | 0.5929 mL | |
| 60 mM | 0.0198 mL | 0.0988 mL | 0.1976 mL | 0.4941 mL | |
| 80 mM | 0.0148 mL | 0.0741 mL | 0.1482 mL | 0.3705 mL | |
| 100 mM | 0.0119 mL | 0.0593 mL | 0.1186 mL | 0.2964 mL |
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