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製品番号: HY-183552

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mCPX

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX) (HY-B0450A). CPX exhibits bacteriostatic and iron-chelating activities, while mCPX enhances the iron stability of CPX. mCPX inherits the core mechanism pathway of CPX and can induce EBV lytic reactivation in EBV⁺ gastric cancer cells via the hypoxia pathway (HIF‑1α). mCPX is applicable to research related to EBV-positive gastric cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1351572-56-9
分子式: C₁₄H₁₉NO₃
分子量:249.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

mCPX 構造式

CAS 番号: 1351572-56-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

HIF/HIF Prolyl-Hydroxylase アイソフォーム固有の製品をすべて表示 :

体外実験

mCPX induces EBV lytic cycle in SNU719 and AGSBX1 EBV⁺ gastric cancer cell lines with activity comparable to CPX, and has significantly greater resistance to iron-mediated inactivation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC	AUC_0-∞	MRT	V_d	CL
Rat^[1]	14 mg/kg	i.p.	10.88 h	0.67 h	3085.04 μg/L	9195.38 μg/L·h	9455.28 μg/L·h	6.67 h	23.25 L/kg	1.48 L/h/kg
Rat^[1]	14 mg/kg	i.g.	5.01 h	1.50 h	511.88 μg/L	4332.53 μg/L·h	4350.86 μg/L·h	6.05 h	23.25 L/kg	3.22 L/h/kg

体内実験

mCPX exhibits superior in vivo antitumor activity to CPX in the SNU719 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1351572-56-9
分子量 249.31
分子式 C₁₄H₁₉NO₃
SMILES

O=C(C)ON(C(C1CCCCC1)=CC(C)=C2)C2=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhuang Y,et al. Targeting lytic cycle with ciclopirox derivative in Epstein-Barr Virus+ gastric cancer. Cancer Research. 2026 Apr 3;86(7_Supplement):213-.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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