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United States

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製品番号: HY-190448

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MD08

MD08 is an inhibitor of Aβ42 fibrillization and Tau aggregation. MD08 improves recognition memory and learning/memory abilities in Aβ-induced cognitive decline mouse models. MD08 does not impair motor coordination in Aβ-injected mice. MD08 has no anticancer activity against neuroblastoma. MD08 can be used for research on Alzheimer's disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₁H₂₀Br₂N₂O₃
分子量:508.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MD08 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Anti-cancerAβ/Tau/α-Synuclein AggregationOthers

Anti-cancer

MD08 (50 μM; 24 h) is non-cytotoxic to SH-SY5Y cells^[1].

Aβ/Tau/α-Synuclein Aggregation

MD08 (50 μM) delays Aβ42 aggregation by modulating primary nucleation in the ThT fluorescence assay^[1].
MD08 (50 μM; 5 h) suppresses Aβ42 fibril formation, as shown by reduced and smaller aggregates in TEM images^[1].
MD08 (100-200 μM; 72 h) inhibits heparin-induced tau aggregation in a concentration-dependent manner, reaching approximately 75% inhibition at 200 μM^[1].

Others

MD08 exhibits moderate passive BBB permeability in the PAMPA-BBB assay with Pe = 3.42 μcm/s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SH-SY5Y
Concentration:

50 μM
Incubation Time:

24 h
Result:

Did not exhibit any significant cytotoxic effects compared with the control group.

体内実験

Aβ/Tau/α-Synuclein Aggregation

MD08 (2-10 mg/kg; i.p.; 14 days) improves cognitive function in Aβ_25-35-injected mice, with the 10 mg/kg i.p. dose producing the greatest reduction in elevated plus maze % ITL and improved novel object recognition at 5 and 10 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino (25-40 g)^[1]
Dosage:

2 mg/kg, 5 mg/kg, and 10 mg/kg
Administration:

i.p.; 14 days
Result:

In the elevated plus maze test, % ITL was reduced to approximately 45% at 2 mg/kg, approximately 40% at 5 mg/kg, and 25% at 10 mg/kg.
In the novel object recognition test, the 2 mg/kg dose did not improve the discrimination index, while 5 mg/kg and 10 mg/kg produced higher discrimination index values.
In the rotarod test, 10 mg/kg did not impair motor coordination.

Related Protocols :

Alzheimer’s Disease Modeling

化学情報

分子量 508.20
分子式 C₂₁H₂₀Br₂N₂O₃
SMILES

BrC1=CC=C(Br)C(CCC(C(NCCC2=CNC3=C2C=C(OC)C=C3)=O)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Das B, et al. Rational design, synthesis, and biological evaluation of indole-piperazine based α-ketoamide derivatives as dual Aβ and tau aggregation modulators for Alzheimer's disease. European journal of medicinal chemistry. 2026 Sep 24;320:119353. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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