オレイン酸メチル
Based on 1 Customer Validation
Methyl oleate is a fatty acid methyl ester (FAME) with anti-extended spectrum β-Lactamase (ESBL) potential, anticancer and antibacterial activities. Methyl oleate substantially improves the antioxidation ability but markedly impaired the antiwear capacity of zinc dialkyldithiophosphate (ZDDP). Methyl oleate is promising for research of ESBL producing multi drug resistant (MDR) pathogens.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- CAS 番号: 112-62-9
- 分子式: C19H36O2
- 分子量:296.49
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
Methyl oleate (80, 100 μg/mL) is effective in inhibiting ESBL producing MDR E. coli and K. pneumoniae[2].
Methyl oleate (25 μg-800 μg, 48 h) exerts an inhibition of A549 cells with an IC50 value of 625 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:25 μg-800 μg
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Incubation Time:48 h
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Result:Lost the cell ability to proliferate by inhibiting cell to cell contact at 24 h and at 48 h all the cells become smaller in size.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lobeo rohita[2]
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Dosage:50-200 mg/L
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Administration:mixed in water, a single dose for 96 h
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Result:Displayed behavioural responses such as hyperventilation, motionless state, increase opercular ventilation, general body weakness, skin discoloration, loss of reflex, erratic swimming, and movement in response to the test chemical in fish.
化学情報
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CAS 番号 112-62-9
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性状 Liquid (Density: 0.874 g/cm3)
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分子量 296.49
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分子式 C19H36O2
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Color Colorless to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC)=O
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別名
Methyl oleate
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 33.33 mg/mL (112.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. Wang J, et al. Engine Oil Degradation Induced by Biodiesel: Effect of Methyl Oleate on the Performance of Zinc Dialkyldithiophosphate.ACS Omega. 2019 Sep 18;4(14):16166-16170. [Content Brief]
[2]. Padmini N, et al. In vitro and in vivo efficacy of methyl oleate and palmitic acid against ESBL producing MDR Escherichia coli and Klebsiella pneumoniae. Microb Pathog. 2020 Nov;148:104446. [Content Brief]
[3]. Niu K, et al. Effects of methyl oleate and microparticle-enhanced cultivation on echinocandin B fermentation titer. Bioprocess Biosyst Eng. 2020 Nov;43(11):2009-2015. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3728 mL | 16.8640 mL | 33.7280 mL | 84.3199 mL |
| 5 mM | 0.6746 mL | 3.3728 mL | 6.7456 mL | 16.8640 mL | |
| 10 mM | 0.3373 mL | 1.6864 mL | 3.3728 mL | 8.4320 mL | |
| 15 mM | 0.2249 mL | 1.1243 mL | 2.2485 mL | 5.6213 mL | |
| 20 mM | 0.1686 mL | 0.8432 mL | 1.6864 mL | 4.2160 mL | |
| 25 mM | 0.1349 mL | 0.6746 mL | 1.3491 mL | 3.3728 mL | |
| 30 mM | 0.1124 mL | 0.5621 mL | 1.1243 mL | 2.8107 mL | |
| 40 mM | 0.0843 mL | 0.4216 mL | 0.8432 mL | 2.1080 mL | |
| 50 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6864 mL | |
| 60 mM | 0.0562 mL | 0.2811 mL | 0.5621 mL | 1.4053 mL | |
| 80 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0540 mL | |
| 100 mM | 0.0337 mL | 0.1686 mL | 0.3373 mL | 0.8432 mL |
Methyl oleate 関連分類
HY-N2598 関連分類
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