Methylstenbolone
Methylstenbolone is a steroid and an anti-inflammatory agent. Methylstenbolone inhibits nitric oxide production in macrophages and exhibits cytotoxicity against breast cancer cells and normal fibroblasts. Methylstenbolone can be used for the research of inflammation and breast cancer.
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- CAS 番号: 6176-38-1
- 分子式: C21H32O2
- 分子量:316.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Methylstenbolone (1-25 μg/mL) potently inhibits nitric oxide production in J774.2 mouse macrophage cells with an IC50 of 10.1 μg/mL[3].
Methylstenbolone (6.25-50 µM; 48 h) is cytotoxic to MCF-7 human breast cancer cells (IC50 = 12.26 μg/mL) and toxic to BJ human fibroblast normal cells (IC50 = 8.69 μg/mL), but shows no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, NCI-H460, HeLa, BJ human fibroblast normal cells
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Concentration:6.25, 12.5, 25, 50 µM
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Incubation Time:48 h
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Result:Exhibited cytotoxicity against MCF-7 breast cancer cells with an IC50 of 12.26 μg/mL.
Showed toxicity toward non-cancerous BJ human fibroblast cells with an IC50 of 8.69 μg/mL.
Showed no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:uPA+/+-SCID chimeric mice transplanted with primary human hepatocytes[1]
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Dosage:1 mg
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Administration:i.g.; single dose
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Result:Detected no parent methylstenbolone compound and metabolites U1-U10, U13 in chimeric mouse urine.
Detected two dihydroxylated metabolites (U11 and U12) in both chimeric and nonchimeric mouse urine.
化学情報
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CAS 番号 6176-38-1
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分子量 316.48
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分子式 C21H32O2
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SMILES
CC1=C[C@]2([C@H](CC1=O)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(O)C)C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Geldof L, et al. Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model. Biomed Chromatogr. 2014;28(7):974-985. [Content Brief]
[2]. Piper T, et al. Studies on the in vivo metabolism of methylstenbolone and detection of novel long term metabolites for doping control analysis. Drug Test Anal. 2019;11(11-12):1644-1655. [Content Brief]
[3]. Aamer M, et al. New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation. Bioorg Chem. 2022;129:106187. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Methylstenbolone 関連分類
HY-W743094 関連分類
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Keywords
- Methylstenbolone
- 6176-38-1
- Drug Derivative
- BJ human fibroblast normal cells
- normal fibroblasts
- macrophages
- MCF-7 human breast cancer cells
- J774.2 mouse macrophage cells
- breast cancer cells
- human liver microsomes
- chimeric mouse urine
- NCI-H460 human lung cancer cells
- HeLa human cervical cancer cells
- Inhibitor
- inhibitor
- inhibit