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製品番号: HY-133760

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MI-888

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1303607-59-1
分子式: C₂₈H₃₂Cl₂FN₃O₃
分子量:548.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI-888 構造式

CAS 番号: 1303607-59-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>10 μM Compound: 9, MI-888	Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
HCT-116	IC₅₀	92 nM Compound: 9, MI-888	Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
RS4-11	IC₅₀	0.06 μM Compound: 9, MI-888	Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
SJSA-1	IC₅₀	0.08 μM Compound: 9, MI-888	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]

化学情報

CAS 番号 1303607-59-1
分子量 548.48
分子式 C₂₈H₃₂Cl₂FN₃O₃
SMILES

CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56(13):5553-61. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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