MitoBloCK-6
Based on 1 publication(s) in Google Scholar
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 303215-67-0
- 分子式: C19H14Cl2N2O
- 分子量:357.23
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 MitoBloCK-6
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生物活性
製品説明
IC50 & Target
IC50: 900 nM (Erv1) 700 nM (ALR) 1.4 μM (Erv2)[1]
体外実験
MitoBloCK-6 (20 μM, 8 h) induces apoptosis via cytochrome c release in human embryonic stem cells (hESCs)[1]. MitoBloCK-6 (20-40 μM, 72 h) inhibits proliferation of liver cancer cells McA-RH7777 via mitochondrial impairment[2]. MitoBloCK-6 kills leukemia cell lines (OCI-AML2, TEX, Jurkat and NB4) with an IC50 of 5-10 µM[3]. MitoBloCK-6 (0.078-5 μM) increases the differentiation of OCI-AML2 and NB4 cells via inhibition of ALR, as increased surface expression of the myeloid markers CD11b[4]. MitoBloCK-6 results in a significant decrease in the growth and branching of developing zebrafish motor neurons via inhibition of ALR[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human embryonic stem cells
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Concentration:20 µM
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Incubation Time:8 h
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Result:Resulted in a shift in cytochrome c localization from mitochondria into the cytosol.
Showed similar number of cells releasing cytochrome c.
Showed downstream events in apoptosis (PARP and caspase-3 cleavage).
体内実験
MitoBloCK-6 (80 mg/kg i.p. 5 of 7 days, 2 weeks) strongly reduces the engraftment of primary AML cells in mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 303215-67-0
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性状 Solid
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分子量 357.23
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分子式 C19H14Cl2N2O
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Color Yellow to orange
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SMILES
OC1=C(/C=N/C2=CC=C(NC3=CC=CC=C3)C=C2)C=C(Cl)C=C1Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation. [Abstract]2026 Jun 10:2026.06.09.731205. PMID: 42327099
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (279.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92. [Content Brief]
[2]. Kabiri Y, et al. Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation. Front Cell Dev Biol. 2021 Sep 20;9:725474. [Content Brief]
[4]. Singh RP, et al. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell. 2020 Jun 4;26(6):926-937.e10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7993 mL | 13.9966 mL | 27.9932 mL | 69.9829 mL |
| 5 mM | 0.5599 mL | 2.7993 mL | 5.5986 mL | 13.9966 mL | |
| 10 mM | 0.2799 mL | 1.3997 mL | 2.7993 mL | 6.9983 mL | |
| 15 mM | 0.1866 mL | 0.9331 mL | 1.8662 mL | 4.6655 mL | |
| 20 mM | 0.1400 mL | 0.6998 mL | 1.3997 mL | 3.4991 mL | |
| 25 mM | 0.1120 mL | 0.5599 mL | 1.1197 mL | 2.7993 mL | |
| 30 mM | 0.0933 mL | 0.4666 mL | 0.9331 mL | 2.3328 mL | |
| 40 mM | 0.0700 mL | 0.3499 mL | 0.6998 mL | 1.7496 mL | |
| 50 mM | 0.0560 mL | 0.2799 mL | 0.5599 mL | 1.3997 mL | |
| 60 mM | 0.0467 mL | 0.2333 mL | 0.4666 mL | 1.1664 mL | |
| 80 mM | 0.0350 mL | 0.1750 mL | 0.3499 mL | 0.8748 mL | |
| 100 mM | 0.0280 mL | 0.1400 mL | 0.2799 mL | 0.6998 mL |
MitoBloCK-6 関連分類
HY-122652 関連分類
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