MK-1220
MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 924270-31-5
- 分子式: C40H53N5O9S
- 分子量:779.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
11 nM
Compound: 15j, MK-1220
|
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
|
[PMID: 24900304] |
| Huh-7 | IC50 |
11 nM
Compound: 2
|
Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS
Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS
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[PMID: 24900473] |
| Huh-7 | IC50 |
4 nM
Compound: 15j, MK-1220
|
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
|
[PMID: 24900304] |
| Huh-7 | IC50 |
5 nM
Compound: 15j, MK-1220
|
Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
|
[PMID: 24900304] |
化学情報
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CAS 番号 924270-31-5
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分子量 779.94
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分子式 C40H53N5O9S
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SMILES
CC(C)(COC(N[C@@H](C1CCCCC1)C(N2[C@H](C(N[C@@](C3)(C(NS(=O)(C4CC4)=O)=O)[C@@H]3C=C)=O)C[C@@H](O5)C2)=O)=O)CCCC6=C(OC)C=C7C(C5=NC=C7)=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MK-1220 関連分類
HY-14404 関連分類
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