MLT-985
Based on 1 publication(s) in Google Scholar
MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.49%
- CAS 番号: 1832576-25-6
- 分子式: C17H15Cl2N9O2
- 分子量:448.27
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 MLT-985
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BJAB | IC50 |
>10 μM
Compound: 11; MLT-985
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Growth inhibition of human BJAB cells grown in soft agar
Growth inhibition of human BJAB cells grown in soft agar
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[PMID: 33216547] |
| OCI-Ly3 | EC50 |
0.12 μM
Compound: 9
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Antiproliferative activity against human OCILY3 cells by cell proliferation assay
Antiproliferative activity against human OCILY3 cells by cell proliferation assay
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[PMID: 31129051] |
| OCI-Ly3 | IC50 |
0.03 μM
Compound: 11; MLT-985
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Inhibition of ROS production in human OCILY3 cells
Inhibition of ROS production in human OCILY3 cells
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[PMID: 33216547] |
| OCI-Ly3 | IC50 |
0.24 μM
Compound: 11; MLT-985
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Growth inhibition of human OCILY3 cells grown in soft agar
Growth inhibition of human OCILY3 cells grown in soft agar
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[PMID: 33216547] |
MLT-985 (19.5-10000 nM, 24 h) inhibits the growth of CARD11 mutant OCI-Ly3 cells growth[1].
MLT-985 (10-1000 nM, 24 h) inhibits MALT1 protease activity in ABC-DLBCL cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ABC-DLBCL cells
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Concentration:10, 50, 100, 500 and 1000 nM
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Incubation Time:24 h
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Result:Blocked cleavage of MALT1 substrates BCL10, CYLD and RELB.
MLT-985 (30 mg/kg, i.g., starting day 13 post-engraftment) prolongs survival in OCI-Ly3 tumor xenograft mice models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OCI-Ly3 tumor xenograft mice models[2]
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Dosage:30 mg/kg
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Administration:Orally gavage, starting day 13 post-engraftment
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Result:Showed median survival of 41 days.
化学情報
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CAS 番号 1832576-25-6
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性状 Solid
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分子量 448.27
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分子式 C17H15Cl2N9O2
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Color White to off-white
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SMILES
CO[C@H](C1=C(NC(NC2=CN=C(N3N=CC=N3)C(Cl)=C2)=O)C=NC4=CC(Cl)=NN14)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Cancer
Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors. [Abstract]2025 Apr;6(4):702-717. PMID: 40075237
溶剤 & 溶解度
DMSO : 100 mg/mL (223.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2308 mL | 11.1540 mL | 22.3080 mL | 55.7700 mL |
| 5 mM | 0.4462 mL | 2.2308 mL | 4.4616 mL | 11.1540 mL | |
| 10 mM | 0.2231 mL | 1.1154 mL | 2.2308 mL | 5.5770 mL | |
| 15 mM | 0.1487 mL | 0.7436 mL | 1.4872 mL | 3.7180 mL | |
| 20 mM | 0.1115 mL | 0.5577 mL | 1.1154 mL | 2.7885 mL | |
| 25 mM | 0.0892 mL | 0.4462 mL | 0.8923 mL | 2.2308 mL | |
| 30 mM | 0.0744 mL | 0.3718 mL | 0.7436 mL | 1.8590 mL | |
| 40 mM | 0.0558 mL | 0.2788 mL | 0.5577 mL | 1.3942 mL | |
| 50 mM | 0.0446 mL | 0.2231 mL | 0.4462 mL | 1.1154 mL | |
| 60 mM | 0.0372 mL | 0.1859 mL | 0.3718 mL | 0.9295 mL | |
| 80 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6971 mL | |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.2231 mL | 0.5577 mL |
MLT-985 関連分類
HY-142648 関連分類
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