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製品番号: HY-181804

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MRS8288

MRS8288 is a ABCG2 and P-glycoprotein inhibitor, with an IC₅₀ of 0.96 μM against ABCG2 and an IC₅₀ of 1.39 μM against P-glycoprotein. MRS8288 inhibits the ATPase activity of ABCG2 and P-glycoprotein, and suppresses ABCG2-mediated substrate transport. MRS8288 is applicable for cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₆H₂₈ClF₂N₉O₃
分子量:708.12

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MRS8288 構造式

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MRS8288 (20 min) potently inhibits the basal ATPase activity of P-glycoprotein derived from High-Five insect cells, with an IC₅₀ of 1.39±0.20 μM^[1].
MRS8288 (20 min) potently inhibits the basal ATPase activity of ABCG2 derived from High-Five insect cells, with an IC₅₀ of 0.96±0.15 μM^[1].
MRS8288 (0-10 μM) potently inhibits ABCG2-mediated transport of Mitoxantrone (HY-13502) and Pheophorbide A (HY-125665) in HEK293-R5 cells, with IC₅₀ values of 2.49±0.16 μM and 4.86±0.4 μM, respectively^[1].
MRS8288 (72 h) exhibits cytotoxicity against both HEK293-pcDNA control cells and HEK293-R5 cells expressing ABCG2, with IC₅₀ values of 5.19±0.1 μM and 4.06±0.6 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 708.12
分子式 C₃₆H₂₈ClF₂N₉O₃
SMILES

O[C@@H]1[C@H](O)[C@](C(NC)=O)(C2)[C@H]2[C@H]1N(C=N3)C4=C3C(NCC5=CC=CC(N6N=NC(C7=CC=C(C=C7)Cl)=C6)=C5)=NC(C#CC8=CC=C(C(F)=C8)F)=N4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Murakami M, et al. (N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters. J Med Chem. 2026;69(4):4945-4968. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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