Multi-Leu peptide
Multi-Leu peptide (ML-peptide) is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1413058-07-7
- 分子式: C49H94N16O9
- 分子量:1051.37
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
100 μM
Compound: 1
|
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 30180568] |
| DU-145 | IC50 |
100 μM
Compound: Ac-LLLLRVKR-NH2
|
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23126600] |
| DU-145 | IC50 |
100 μM
Compound: ML
|
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 24350995] |
| DU-145 | IC50 |
25 μM
Compound: 1
|
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 30501188] |
| LNCaP | IC50 |
180 μM
Compound: 1
|
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 30180568] |
| LNCaP | IC50 |
180 μM
Compound: Ac-LLLLRVKR-NH2
|
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23126600] |
| LNCaP | IC50 |
180 μM
Compound: ML
|
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 24350995] |
| LNCaP | IC50 |
45 μM
Compound: 1
|
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 30501188] |
化学情報
-
CAS 番号 1413058-07-7
-
分子量 1051.37
-
分子式 C49H94N16O9
-
別名
ML-peptide, Multi-Leucine (ML)-peptide
-
配列
Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
-
シーケンスの短縮
Ac-LLLLRVKR-NH2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)