N6F11
Based on 1 publication(s) in Google Scholar
N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8+ T cells.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.11%
- CAS 番号: 851398-76-0
- 分子式: C13H8Cl2N2OS
- 分子量:311.19
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-Cancer Compound Library
HY-L025
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Ferroptosis Compound Library
HY-L051
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Transcription Factor-Targeted Library
HY-L090
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
MedChemExpress（MCE）の使用を引用している文献 N6F11
More
生物活性
N6F11 (5 μM, 12 h) suppresses GPX4 expression through enhanced protein degradation instead of through reduced gene transcription, induces autophagy-independent ferroptosis in PANC1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 851398-76-0
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性状 Solid
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分子量 311.19
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分子式 C13H8Cl2N2OS
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Color Off-white to light yellow
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SMILES
ClC1=CC=C(C2=CC3=C(C(NC(CCl)=N3)=O)S2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Discov
Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer. [Abstract]2025 Sep 25;11(1):423. PMID: 40998801
溶剤 & 溶解度
DMSO : 31.25 mg/mL (100.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li J, et al. Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. Sci Transl Med. 2023;15(720):eadg3049. [Content Brief]
[2]. Liu J, et al. Cell type-specific induction of ferroptosis to boost antitumor immunity. Oncoimmunology. 2023 Nov 20;12(1):2282252. [Content Brief]
[3]. Shi TM, et al. Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer. J Med Chem. 2024 Feb 22;67(4):2238-2263. [Content Brief]
[4]. Liu J, et al. Adverse effects of ferroptotic therapy: mechanisms and management. Trends Cancer. 2024 May;10(5):417-429. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2135 mL | 16.0674 mL | 32.1347 mL | 80.3368 mL |
| 5 mM | 0.6427 mL | 3.2135 mL | 6.4269 mL | 16.0674 mL | |
| 10 mM | 0.3213 mL | 1.6067 mL | 3.2135 mL | 8.0337 mL | |
| 15 mM | 0.2142 mL | 1.0712 mL | 2.1423 mL | 5.3558 mL | |
| 20 mM | 0.1607 mL | 0.8034 mL | 1.6067 mL | 4.0168 mL | |
| 25 mM | 0.1285 mL | 0.6427 mL | 1.2854 mL | 3.2135 mL | |
| 30 mM | 0.1071 mL | 0.5356 mL | 1.0712 mL | 2.6779 mL | |
| 40 mM | 0.0803 mL | 0.4017 mL | 0.8034 mL | 2.0084 mL | |
| 50 mM | 0.0643 mL | 0.3213 mL | 0.6427 mL | 1.6067 mL | |
| 60 mM | 0.0536 mL | 0.2678 mL | 0.5356 mL | 1.3389 mL | |
| 80 mM | 0.0402 mL | 0.2008 mL | 0.4017 mL | 1.0042 mL | |
| 100 mM | 0.0321 mL | 0.1607 mL | 0.3213 mL | 0.8034 mL |
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