Naratuximab
Based on 1 publication(s) in Google Scholar
Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 1622327-39-2
- 分子量:143.6 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 Naratuximab
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生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
TSPAN26/CD37
体外実験
Naratuximab emtansine (IMGN529), an ADC comprised of DM1 linked to a humanized anti-CD37 antibody via the same linker used in Kadcyla. Naratuximab emtansine effectively combines the intrinsic proapoptotic and effector activities of its antibody component with the cytotoxic activity of the maytansinoid payload[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized hu-CD37-VLP can bind Naratuximab. The EC50 for this effect is 4.061 ng/mL. -
Flow Cytometry analysis of Raji cells labelling CD37 (red) with Naratuximab (anti-CD37) (HY-P99374). Goat Anti-Human IgG (FITC) (ZF-0308) at a dilution of 1/100 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
化学情報
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CAS 番号 1622327-39-2
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性状 Liquid
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分子量 143.6 kDa
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Color Colorless to light yellow
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SMILES
[Naratuximab]
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別名
Anti-TSPAN26/CD37 Reference Antibody (naratuximab)
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice. [Abstract]2025 Jul 18;16(1):6610. PMID: 40675974
純度とドキュメンテーション
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データシート (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)