Nimucitinib
Based on 1 Customer Validation
Nimucitinib is a selective JAK inhibitor with potent tear secretion-promoting activity. Nimucitinib downregulates relevant signal transduction pathways by inhibiting the catalytic activity of JAK family tyrosine kinases. Nimucitinib promotes tear secretion in rabbits and inhibits corneal injury in rats. Nimucitinib can be used in dry eye-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.27%
- CAS 番号: 2740557-24-6
- 分子式: C25H26F2N6O2
- 分子量:480.51
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Immunology/Inflammation Compound Library
HY-L007
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JAK/STAT Compound Library
HY-L008
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Kinase Inhibitor Library
HY-L009
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HY-L016
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生物活性
Nimucitinib (0.01% solution, administered via ocular instillation, 50 μL per dose, four times daily for 10 consecutive days) promotes tear secretion in a rabbit model of atropine-induced dry eye[1].
Nimucitinib (0.003-0.01% solution; eye drop; 6 times per day for 11 consecutive days; 5 μL each time) inhibits corneal injury in a rat model of dry eye induced by extraorbital lacrimal gland excision[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:JW white rabbit (male, weight ~2 kg)[1]
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Dosage:0.001% solution; 0.01% solution
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Administration:ocular instillation; single dose; 50 μL
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Result:Increased tear volume by 131% compared to pre-administration in the 0.001% solution group.
Increased tear volume by 168% compared to pre-administration in the 0.01% solution group.
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Animal Model:JW white rabbit (male, weight ~2 kg, atropine-induced dry eye model)[1]
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Dosage:0.01% solution
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Administration:ocular instillation; 4 times daily; 10 days; 50 μL
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Result:Increased tear volume by 151% compared to pre-administration.
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Animal Model:SD rat (male, 6 weeks old, extraorbital lacrimal gland excision-induced dry eye model)[1]
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Dosage:0.003% solution; 0.01% solution
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Administration:ocular instillation; 6 times daily; 11 days; 5 μL
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Result:Resulted in a corneal damage score of 13.0 in the 0.003% solution group.
Resulted in a corneal damage score of 10.5 in the 0.01% solution group.
化学情報
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CAS 番号 2740557-24-6
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性状 Solid
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分子量 480.51
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分子式 C25H26F2N6O2
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Color Off-white to light yellow
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SMILES
FC1=CC(F)=CC(CNC2=CC(NC3=CC(NC([C@H]4CCCNC4)=O)=CC=C3)=NC=C2C(N)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (260.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0811 mL | 10.4056 mL | 20.8112 mL | 52.0281 mL |
| 5 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4056 mL | |
| 10 mM | 0.2081 mL | 1.0406 mL | 2.0811 mL | 5.2028 mL | |
| 15 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
| 20 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6014 mL | |
| 25 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
| 30 mM | 0.0694 mL | 0.3469 mL | 0.6937 mL | 1.7343 mL | |
| 40 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
| 50 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0406 mL | |
| 60 mM | 0.0347 mL | 0.1734 mL | 0.3469 mL | 0.8671 mL | |
| 80 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6504 mL | |
| 100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL |
Nimucitinib 関連分類
HY-148785 関連分類
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