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製品番号: HY-184558

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NP7r

NP7r is an antioxidant and neuroprotective agent. NP7r regulates oxidative stress, upregulates downstream antioxidant genes, reduces mitochondrial ROS, initiates Autophagy and clears α-synuclein aggregates. NP7r alleviates dopaminergic neuron degeneration, restores fat content, reduces lipid peroxidation, and improves motor impairment and abnormal food perception. NP7r is applicable to the research of Parkinson's disease.

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CAS 番号: 2641092-28-4
分子式: C₂₆H₂₀O₃
分子量:380.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NP7r 構造式

CAS 番号: 2641092-28-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

α-synuclein アイソフォーム固有の製品をすべて表示 :

体内実験

NP7r (10-80 μM; 48 h) exerts neuroprotective effects in an α-synuclein-expressing C. elegans Parkinson's disease model, with mechanisms involving a statistically significant reduction in mitochondrial ROS levels, approximately 30% decrease in α-synuclein aggregation, and upregulation of antioxidant and autophagy-related pathways^[1].
NP7r (10 μM) protects *Caenorhabditis elegans* against 6-OHDA (HY-B1081)-induced dopaminergic neuron degeneration, restoring the total fluorescence intensity of dopaminergic neurons to 96.28% of that in the control group^[1].
NP7r (10 μM) alleviates 6-OHDA-induced growth and behavioral defects in wild-type *Caenorhabditis elegans*, restoring its movement and feeding-related behaviors to levels close to those of the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NL5901 pkIs2386 [unc-54p::alpha-synuclein:YFP + unc-119(+)]^[1]
Dosage:

10 μM; 20 μM; 40 μM; 80 μM
Administration:

nematode growth medium; 48 hours
Result:

Significantly reduced mitochondrial ROS levels in NL5901 worms (effect dependent on skn-1 gene).
Decreased α-synuclein-YFP fluorescence intensity by ~30% relative to untreated controls.
Reduced MDA levels and partially restored lipid droplet area in NL5901 worms.
Upregulated mRNA levels of skn-1, gst-4, gcs-1, cct-2, cct-3, cct-4, cct-6, cct-7, cct-8, lgg-1, unc-51, epg-5, epg-8, vps-35, and atg-7.
Downregulated daf-16 and sod-3 mRNA levels.
Increased GSH levels and restored GST-4::GFP fluorescence intensity in 6-OHDA-treated CL2166 worms.
Confirmed α-synuclein clearance effect dependent on cct-6, lgg-1, and unc-51 genes.

Animal Model:

BZ555 egls1[Pdat-1::gfp]^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored total dopaminergic neuron fluorescence intensity to 96.28% of untreated BZ555 levels, representing a 36.23% increase relative to 6-OHDA-only treated worms.
Restored fluorescence intensity of cephalic (CEP), anterior deirid (ADE), and posterior deirid (PDE) dopaminergic neurons.

Animal Model:

N2^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored 6-OHDA-reduced body length, tail thrashing frequency, slowing rate, travel distance, velocity, and body bend frequency in N2 worms to levels statistically comparable to untreated controls.

化学情報

CAS 番号 2641092-28-4
分子量 380.44
分子式 C₂₆H₂₀O₃
SMILES

O=C1CCC2=C1C(C3=CC=CC=C3)=CC(C4=CC=C(C=C4)O)(O2)C5=CC=CC=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Han RT, et al. Pyran compound 7r exerts neuroprotective effects against Parkinson's disease via modulating oxidative stress and autophagy. iScience. 2026 Jun 8;29(6):116233. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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化学情報
純度とドキュメンテーション
参考文献

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NP7r

α-synuclein アイソフォーム固有の製品をすべて表示