country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-D3152

Copy Link Print Information

NRh-Cu

NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu²⁺-selective probe (λ_ex=680 nm, λ_em=740 nm). When NRh-Cu interacts with Cu²⁺, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu²⁺ imaging in live cells and in vivo.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2361979-91-9
分子式: C₄₉H₅₅N₅O₃
分子量:761.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NRh-Cu 構造式

CAS 番号: 2361979-91-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

NRh-Cu (10 μM) exhibits high selectivity for Cu²⁺ over a wide range of other metal ions in ethanol/H₂O solution, with a rapid fluorescence turn-on response reaching maximum intensity within 10 min; with a fluorescence-based detection limit of 0.95 ppb and absorption-based detection limit of 6.2 ppb^[1].
NRh-Cu (2-80 μM; 48 h) shows no significant cytotoxicity toward HeLa cells^[1].
NRh-Cu (10 μM; 1 h) exhibits good membrane permeability in HeLa cells and generates strong fluorescence in the presence of intracellular Cu²⁺^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cells
Concentration:

2-80 μM
Incubation Time:

48 h
Result:

Showed no significant difference in HeLa cell proliferation after incubation at concentrations from 2 to 80 μM for 48 h.

体内実験

NRh-Cu (0.2 mL, 0.2 mg/mL; intravenous injection; single dose) binds to systemic Cu²⁺ in living mice, and the in vivo near-infrared fluorescence emission intensity increases significantly^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice (male, 4 weeks old, ~20 g)^[1]
Dosage:

0.2 mL, 0.2 mg/mL
Administration:

i.v.; single dose
Result:

Showed low fluorescence emission intensity when administered alone.
Showed a significant increase in fluorescence emission intensity when followed by systemic Cu²⁺ administration compared to the NRh-Cu-only group.

化学情報

CAS 番号 2361979-91-9
分子量 761.99
分子式 C₄₉H₅₅N₅O₃
SMILES

CCN(C1=CC=C2C(OC3=C(C24C5=C(C(N4/N=C/C6=CC=C(C=C6O)N(CC)CC)=O)C=CC=C5)CCC/C3=C\C=C7N(C8=C(C/7(C)C)C=CC=C8)CC)=C1)CC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Xu Z, et al. Near-infrared fluorescent probe for selective detection of Cu2+ in living cells and in Vivo[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 216: 404-410.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ