NSC804515
NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H25F2N5O2S
- 分子量:509.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
NSC804515 exhibits drastically reduced inhibitory potency against purified human p97 resistance mutants p97P510S, p97N616F, and p97F618S (over 30-fold higher IC50) and p97K512N (12-fold higher IC50) compared to wild-type p97[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 509.57
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分子式 C26H25F2N5O2S
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SMILES
FC1=CC(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CN=CC=C4)=C(F)C=C1C#CCNC(CC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NSC804515 関連分類
HY-168007 関連分類
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Keywords
- NSC804515
- NSC 804515
- NSC-804515
- p97
- VCP
- Cdc48
- p97R155H
- R155H mutant human p97/VCP ATPase
- cancer
- UbG76V-GFP
- p97WT
- inclusion body myopathy with early-onset paget disease and frontotemporal dementia
- familial amyotrophic lateral sclerosis
- ubiquitin-proteasome system
- human p97/VCP ATPase
- D1-D2 domain interface
- Inhibitor
- inhibitor
- inhibit