OGT-719
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 185843-61-2
- 分子式: C10H13FN2O7
- 分子量:292.22
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
OGT-719 (80 mM, 4 h) inhibits thymidylate synthase (TS) activity in C170HM2 cells at a concentration of 80 mM (approximately 2xIC50)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male MFI nude mice injected with C170HM2 cells into the peritoneal cavity[1]
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Dosage:1500 mg/kg/day
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Administration:p.o., b.i.d. for 32 days
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Result:Showed a significant 70% reduction in mean liver tumor burden.
Showed a significant decrease in mean liver tumor cross-sectional areas.
Showed no significant effect on animal weight.
化学情報
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CAS 番号 185843-61-2
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分子量 292.22
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分子式 C10H13FN2O7
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SMILES
O=C1NC(C(F)=CN1[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OGT-719 関連分類
HY-19272 関連分類
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