製品番号: HY-147092

オリザリン

(別名: Oryzalin)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.62%
CAS 番号: 19044-88-3
分子式: C₁₂H₁₈N₄O₆S
分子量:346.36

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oryzalin 構造式

CAS 番号: 19044-88-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

MedChemExpress（MCE）の使用を引用している文献 Oryzalin

Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]

Customer Validation & Images

Cell Imaging/Staining

Cell Imaging/Staining

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	800 nM Compound: 2	Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs	[PMID: 21889338]
HFF	IC₅₀	0.25 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.26 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.4 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.5 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.6 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	14.7 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	16 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.2 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.3 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	25.3 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	27.7 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	5.5 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]
J774	IC₅₀	44 μM Compound: 2 (Oryzalin)	In vitro cytotoxicity against mouse J774 macrophages. In vitro cytotoxicity against mouse J774 macrophages.	[PMID: 15027874]
PC-3	IC₅₀	56 μM Compound: 2 (Oryzalin)	In vitro cytotoxicity against mouse PC3 prostate cancer cell line. In vitro cytotoxicity against mouse PC3 prostate cancer cell line.	[PMID: 15027874]

体外実験

Oryzalin (0.1 μM; 5 min) inhibits anaphase chromosome migration, depolymerizes microtubules, and prevents the polymerization of new microtubules at all stages of the mitotic cycle in the endosperm cells of Haemanthus katherinae Bak^[1].
Oryzalin (5-30 μM; in agar solution for 20-30 days) can double the chromosomes in isolated haploid apple stem segments with high survival rate and efficiency^[2].
Oryzalin (6-500 μM; 1 h) has high hemolytic activity in human red blood cells, with a hemolysis rate of approximately 20% at 100 μM^[2].
Oryzalin (6-50 μM; 48 h) has antileishmanial activity in THP-1 cells infected with L. infantum, with an IC₅₀ of 24.2 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 19044-88-3
性状 Solid
分子量 346.36
分子式 C₁₂H₁₈N₄O₆S
Color Orange to red
SMILES

O=S(C1=CC([N+]([O-])=O)=C(N(CCC)CCC)C([N+]([O-])=O)=C1)(N)=O
別名

Oryzalin
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All Cell Imaging/Staining

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Journal Impact Factor

Nat Commun

ATG8ylation-mediated tonoplast invagination mitigates vacuole damage. [Abstract]

2025 Jul 18;16(1):6621. PMID: 40681515

Oryzalin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]

Oryzalin (10 μM) and latrunculin B (10 μM) were employed to disrupt microtubule and microfilament structures, respectively.

溶剤 & 溶解度

体外:

DMSO : 233.33 mg/mL (673.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8872 mL

14.4358 mL

28.8717 mL

5 mM

0.5774 mL

2.8872 mL

5.7743 mL

10 mM

0.2887 mL

1.4436 mL

2.8872 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (623 KB)
- English - EN (623 KB)
- Français - FR (623 KB)
- Deutsch - DE (623 KB)
- Norwegian - NO (623 KB)
- Español - ES (623 KB)
- Swedish - SV (623 KB)
- Italian - IT (623 KB)
- Korean - KR (623 KB)
- Portuguese - PT (623 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172(2):252-64. [Content Brief]

[2]. Bouvier L, et al. Oryzalin as an efficient agent for chromosome doubling of haploid apple shoots in vitro. Plant Breeding, 1994, 113(4): 343-346.

[3]. Lopes RM, et al. Formulation of oryzalin (ORZ) liposomes: in vitro studies and in vivo fate. Eur J Pharm Biopharm. 2012 Oct;82(2):281-90. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8872 mL	14.4358 mL	28.8717 mL	72.1792 mL
	5 mM	0.5774 mL	2.8872 mL	5.7743 mL	14.4358 mL
	10 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2179 mL
	15 mM	0.1925 mL	0.9624 mL	1.9248 mL	4.8119 mL
	20 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	25 mM	0.1155 mL	0.5774 mL	1.1549 mL	2.8872 mL
	30 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	40 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	80 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL

Keywords

Oryzalin

1 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Oryzalin

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

オリザリン

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Anti-Lung Cancer Compound Library

Protein-protein Interaction Inhibitor Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Environmental Pollutant Compound Library

MedChemExpress（MCE）の使用を引用している文献 Oryzalin

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Oryzalin 関連分類

HY-147092 関連分類