OX2-2303
OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research.
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- CAS 番号: 1607428-33-0
- 分子式: C23H21FN4O2S
- 分子量:436.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Orexin Receptor (OX Receptor) アイソフォーム固有の製品をすべて表示
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生物活性
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OX2 Receptor 0.1 nM (Ki) |
OX2-2303 (compound 1) exhibits no significant off-target activity across a panel of 59 major CNS targets, with exception of low affinity binding to sigma-2 (Ki = 2681 nM) and NR2B receptors (Ki = 9475 nM)[1].
OX2-2303 shows favorable tracer integrity, with no appreciable radiometabolites detected in saline, serum (mouse, rat, nonhuman primate, and human), and liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1607428-33-0
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分子量 436.50
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分子式 C23H21FN4O2S
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SMILES
FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OX2-2303 関連分類
HY-178871 関連分類
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