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製品番号: HY-16375

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Ozarelix

Name: Ozarelix
Brand: MedChemExpress
SKU: HY-16375
Availability: PreOrder

(別名: D-63153)

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 295350-45-7
分子式: C₇₂H₉₆ClN₁₇O₁₄
分子量:1459.09

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ozarelix 構造式

CAS 番号: 295350-45-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer^[1].

体外実験

Ozarelix (0-20 ng/mL, 72 h) inhibits PC3 and DU145 cell proliferation^[1].
Ozarelix (0-20 ng/mL, 72 h) induces apoptosis in PC3 and DU145 cells^[1].
Ozarelix (20 ng/mL, 72 h) triggers caspase 8-dependent caspase 3 activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Serum-starved PC3 and DU145 cells
Concentration:

0, 5, 10, 20 ng/mL
Incubation Time:

0, 24, 48, 72, 96 h
Result:

Inhibited cell proliferation in a dose and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

PC3 and DU145 cells
Concentration:

0, 5, 10, 20 ng/mL
Incubation Time:

72 h
Result:

Increased the levels of p21 and p27 both in PC3 and DU145 cells.
Decreased levels of anti-apoptotic proteins such as Bcl2 and Bcl-Xl.
Upregulated Erk and p38MAPK activity.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 295350-45-7
分子量 1459.09
分子式 C₇₂H₉₆ClN₁₇O₁₄
別名

D-63153
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (259 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Festuccia C, et al. Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Prostate. 2010 Sep 1;70(12):1340-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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