P-gp modulator-4
P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp). P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C40H68N2O6
- 分子量:672.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HK-2 | IC50 |
63.07 μM
Compound: 4c
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Cytotoxicity against human HK-2 cells assessed as cell survival measured after 72 hrs incubation by MTT assay
Cytotoxicity against human HK-2 cells assessed as cell survival measured after 72 hrs incubation by MTT assay
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[PMID: 38704938] |
| HUVEC | IC50 |
>100 μM
Compound: 4c
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Cytotoxicity against HUVEC cells assessed as cell survival measured after 72 hrs incubation by MTT assay
Cytotoxicity against HUVEC cells assessed as cell survival measured after 72 hrs incubation by MTT assay
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[PMID: 38704938] |
化学情報
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分子量 672.98
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分子式 C40H68N2O6
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SMILES
CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CC6CN(C(OC(C)(C)C)=O)C6)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
P-gp modulator-4 関連分類
HY-161645 関連分類
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