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製品番号: HY-P99041

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Biologically Validated

Panitumumab

(別名: ABX-EGF)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.77%
CAS 番号: 339177-26-3
分子量:144.32 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Panitumumab 構造式

CAS 番号: 339177-26-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Verified Bioactivity
化学情報
Publications (2)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

EGFR

EGFR アイソフォーム固有の製品をすべて表示 :

体外実験

Panitumumab (2 nM-2 μM, 3 h) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells^[3].
Panitumumab (0-200 μg/mL, 48 h) inhibits the proliferation of DLD-1 cells^[4].
Panitumumab (80 μg/mL, 24 h) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
Concentration:

2, 20, 200, 2000 nM
Incubation Time:

3 h
Result:

Inhibited ligand-induced autophosphorylation of EGFR.

体内実験

Panitumumab (25-500 μg per mouse, i.p., twice a week) inhibits tumor growth in the xenograft models of NCI-H1975 and NCI-H1650 in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCI-H1975 and NCI-H1650 xenografts^[3]
Dosage:

25, 100, or 500 μg/mouse
Administration:

Intraperitoneal injection (i.p.), twice a week
Result:

Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.

遺伝子ID

1956 [NCBI]

アクセッション番号

P00533-1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

アプリケーション

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized EGFR Protein, Human can bind Panitumumab. The EC₅₀ for this effect is 47.19 ng/mL.
Panitumumab has a significant ADCP effect on CHOK1-human EGFR cells in a dose-dependent manner.The EC₅₀ for this effect is 130.4 ng/mL.

化学情報

CAS 番号 339177-26-3
性状 Liquid
分子量 144.32 kDa
Color Colorless to light yellow
SMILES

[Panitumumab]
別名

ABX-EGF
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All WBIF

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Journal Impact Factor

Sci Rep

Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. [Abstract]

2022 Jul 7;12(1):11561. PMID: 35798841

Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561. [Abstract]

HeLa cells were pretreated with 100 nM cetuximab (Cmab) or 30 nM panitumumab (Pmab) for 10 min and then stimulated with 20 ng/mL TNF-α for 15 or 60 min. The expression of the indicated proteins was detected by immunoblotting.

Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561. [Abstract]

Panitumumab (100 nM, 25 min) was internalized upon stimulation with TNF-α (20 ng/mL, 15 min) in HeLa cells.
Electrophoresis

A Separation Buffers Platform Set to Facilitate CZE Charge Heterogeneity Method Development for Monoclonal Antibodies. [Abstract]

2026 Mar 24. PMID: 41873887

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Giannopoulou E, et al. Autophagy: novel action of panitumumab in colon cancer. Anticancer Res. 2009 Dec;29(12):5077-82. PMID: 20044619.. . . [Content Brief]

[2]. Yu Jo Chua, et al. Panitumumab. Drugs Today (Barc). 2006 Nov;42(11):711-9. [Content Brief]

[3]. Stefan Stremitzer, et al. Panitumumab safety for treating colorectal cancer. Expert Opin Drug Saf. 2014 Jun;13(6):843-51. [Content Brief]

[4]. Daniel J. Freeman, et al. Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. Mol Cancer Ther (2009) 8 (6): 1536–1546. [Content Brief]

[5]. Efstathia Giannopoulou, et al. Autophagy: novel action of panitumumab in colon cancer. Anticancer Res. 2009 Dec;29(12):5077-82.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Panitumumab

2 Cited Publications

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Biological Activity
化学情報
Publications (2)
純度とドキュメンテーション
参考文献

1/16

Human IgG2 kappa
1/16

Immobilized EGFR Protein, Human can bind Panitumumab. The EC₅₀ for this effect is 47.19 ng/mL.
1/16

Panitumumab has a significant ADCP effect on CHOK1-human EGFR cells in a dose-dependent manner.The EC₅₀ for this effect is 130.4 ng/mL.
1/16

Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561. [Abstract]

Customer Validation
HeLa cells were pretreated with 100 nM cetuximab (Cmab) or 30 nM panitumumab (Pmab) for 10 min and then stimulated with 20 ng/mL TNF-α for 15 or 60 min. The expression of the indicated proteins was detected by immunoblotting.
1/16

Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561. [Abstract]

Customer Validation
Panitumumab (100 nM, 25 min) was internalized upon stimulation with TNF-α (20 ng/mL, 15 min) in HeLa cells.
1/16

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Panitumumab

Antibody Inhibitor Library

MedChemExpress（MCE）の使用を引用している文献 Panitumumab

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Panitumumab

Antibody Inhibitor Library

MedChemExpress（MCE）の使用を引用している文献 Panitumumab

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Panitumumab 関連分類

HY-P99041 関連分類