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United States

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製品番号: HY-P12013

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PEG12KL4

PEG12KL4 is a PEG-modified amphipathic cell-penetrating peptide. PEG12KL4 promotes the transfection and delivery of mRNA into lung cells, maintains mRNA stability, and forms mRNA complexes that retain integrity and translatability. PEG12KL4 endows lipid nanoparticles (LNPs) with anti-nebulization properties, enhances transfection efficiency in artificial mucus when used in combination with LNPs, and enables the formation of dry powder formulations with low toxicity and mild inflammatory responses. PEG12KL4 can be used in studies related to drug delivery for pulmonary diseases (cystic fibrosis, chronic obstructive pulmonary disease).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₅₃H₂₉₁N₂₇O₃₅
分子量:3069.11

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PEG12KL4 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

PEG12KL4 (1.5-40 mol%; at least 30 min)-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain stable hydrodynamic size, polydispersity index, zeta potential, and encapsulation efficiency following nebulisation^[1].
PEG12KL4-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain consistent mRNA transfection efficiency in A549 cells following nebulisation^[1].
PEG12KL4 forms stable mRNA complexes that can be processed into dry powder aerosols via spray drying and spray freeze drying while preserving mRNA integrity and translational capability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 3069.11
分子式 C₁₅₃H₂₉₁N₂₇O₃₅
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O
配列

PEG12-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-NH2
シーケンスの短縮

PEG12-KLLLLKLLLLKLLLLKLLLLK-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ma C. The combination of PEG12KL4 peptide and lipid nanoparticles (LNPs) for pulmonary mRNA delivery via nebulisation. DDL2025, 2025.

[2]. Yokoo H, et al. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery. Pharmaceutics. 2021 Dec 29;14(1):78. [Content Brief]

[3]. He X, et al. Nonviral targeted mRNA delivery: principles, progresses, and challenges. MedComm. 2025 Jan;6(1):e70035. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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