Penitrem B
Penitrem B (Tremortin B) is a dechlorinated indole diterpene tremorgen found in fungi such as Penicillium palitans and Aspergillus sulphureus. Penitrem B induces tremors, ataxia, and convulsions in mice. Penitrem B is used in research related to tremogenic mycotoxicosis and fungal infections.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 11076-67-8
- 分子式: C37H45NO5
- 分子量:583.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Penitrem B exhibits weak or no cytotoxic activity against A549 and HL-60 cell lines[1].
Penitrem B is obtained by extraction and purification from Fernbach cultures of Penicillium palitans NRRL 3468, with a yield of approximately 25 mg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (18-24 g)[2]
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Dosage:1.38, 2.76, 5.52 and 11.04 mg/kg
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Administration:i.p.; single dose
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Result:Caused perceptible tremors at doses as low as 1.3 mg/kg which persisted for several hours.
Caused 3 deaths out of 4 animals at 5.52 mg/kg.
Caused 4 deaths out of 4 animals at 11.04 mg/kg.
Calculated an LD50 of 5.84 mg/kg with a 95% confidence interval of 4.13 to 8.26 mg/kg.
化学情報
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CAS 番号 11076-67-8
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分子量 583.76
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分子式 C37H45NO5
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SMILES
O[C@]12[C@]34[C@]([C@H]([C@H](O[C@]4([H])CC[C@@]1([C@]5(C6=C7[C@](OC(C)([C@]8([H])[C@@]9([H])C%10=C7C(N6)=CC=C%10CC([C@@]9([H])C8)=C)C)([H])[C@]5([H])CC2)C)C)C(C)=C)O)([H])O3
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別名
Tremortin B
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Structure Classification
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Initial Source
Penicillium crustosum
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gao SS, et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. J Nat Prod. 2016 Aug 26;79(8):2066-74. [Content Brief]
[4]. Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon : official journal of the International Society on Toxinology. 2012 Dec 15;60(8):1428-35. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Penitrem B 関連分類
HY-N22059 関連分類
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