Peptide 22
Peptide 22 is a polypeptide that binds to EGFR. Peptide 22 competes with endogenous EGF for EGFR binding sites and is taken up by triple-negative breast cancer cells in a dose-dependent manner. Peptide 22 can be used in studies related to triple-negative breast cancer.
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- CAS 番号: 3030200-17-7
- 分子式: C75H96N16O20
- 分子量:1541.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
Peptide 22 (YHWYGYTPENVI) (2 μM) specifically binds to EGFR on MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells, with significantly higher uptake than the parent GE11 peptide and dose-dependent binding saturation at 2 μM in MDA-MB-231 cells[1].
Peptide 22 shows high uptake in MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells but has low serum stability, requiring cyclization to enhance in vivo utility[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3030200-17-7
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分子量 1541.66
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分子式 C75H96N16O20
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SMILES
O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H]([C@H](O)C)C(N6[C@@H](CCC6)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC7=CC=C(C=C7)O)N
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配列
Tyr-His-Trp-Tyr-Gly-Tyr-Thr-Pro-Glu-Asn-Val-Ile
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シーケンスの短縮
YHWYGYTPENVI
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Peptide 22 関連分類
HY-P11944 関連分類
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