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製品番号: HY-N21762

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Petatewalide A

Petatewalide A is a bakkenolide-type sesquiterpene. Petatewalide A is isolated from Petasites tatewakianus. Petatewalide A inhibits NO production. Petatewalide A exhibits anticancer activity against cervical cancer, breast cancer, and Lewis lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1280717-80-7
分子式: C₂₂H₃₀O₆
分子量:390.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Petatewalide A 構造式

CAS 番号: 1280717-80-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NO Synthase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	93.3 μM	Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound. Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound.	19686812
MCF7	IC50	114.3 μM	Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound. Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound.	19686812
BV-2	IC50	84.1 μM	Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs. Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs.	25188451

体外実験

Anti-cancerInnate ImmunityCytokines & Chemokines

Anti-cancer

Petatewalide A exhibits weak cytotoxic activity against the HeLa, MCF-7, and LLC cancer cell lines, with the most potent effect against the LLC cell line (IC₅₀ = 77.9 μM)^[1].

Innate Immunity

Cytokines & Chemokines

Petatewalide A (20 h) moderately inhibits LPS-induced NO production in murine microglial BV-2 cells with an IC₅₀ value of 84.1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

化学情報

CAS 番号 1280717-80-7
分子量 390.48
分子式 C₂₂H₃₀O₆
SMILES

O(C(C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=C(C)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dong XW, et al. Bakkenolides from Petasites tatewakianus. Fitoterapia. 2010 Apr;81(3):153-6. [Content Brief]

[2]. Wang M, et al. Characterization and NO inhibitory activities of chemical constituents from an edible plant Petasites tatewakianus. Journal of agricultural and food chemistry. 2014 Sep 24;62(38):9362-7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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